동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제20권4호
  • /
  • Pages.951-956
  • /
  • 2006
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

흑삼의 제조 및 항암효과

Preparation of Black Ginseng and its Antitumor Activity

  • 이지현 (충남대학교 약학대학) ;
  • 신귀남 (충남대학교 약학대학) ;
  • 김의검 (충남대학교 약학대학) ;
  • 신현중 ((주)금산천년홍삼) ;
  • 명창선 (충남대학교 약학대학) ;
  • 오한진 (성균관대학교 의과대학) ;
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 노성수 (대전대학교 한의과대학 본초학교실) ;
  • 조원 (대전대학교 한의과대학 본초학교실) ;
  • 서영배 (대전대학교 한의과대학 본초학교실) ;
  • 박용진 (백남한의원) ;
  • 강철우 (백남한의원) ;
  • 송규용 (충남대학교 약학대학)
  • Lee, Jee-Hyun (College of Pharmacy, Chungnam National University) ;
  • Shen, Gui-Nan (College of Pharmacy, Chungnam National UniversityCollege of Pharmacy, Chungnam National University) ;
  • Kim, Eui-Keom (College of Pharmacy, Chungnam National University) ;
  • Shin, Hyun-Joong (Geum-San Chun-Yun Red Ginseng Co. Ltd.) ;
  • Myung, Chang-Seon (College of Pharmacy, Chungnam National University) ;
  • Oh, Han-Jin (Cheil General Hospital & Women's Health Care Center, Sungkyunkwan University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Daejon University) ;
  • Roh, Seong-Soo (Department of Herbalogy, College of Oriental Medicine, Daejon University) ;
  • Cho, Won (Department of Herbalogy, College of Oriental Medicine, Daejon University) ;
  • Seo, Young-Bae (Department of Herbalogy, College of Oriental Medicine, Daejon University) ;
  • Park, Yong-Jin (Baeknam Oriental Medical Hospital) ;
  • Kang, Cheol-Woo (Baeknam Oriental Medical Hospital) ;
  • Song, Gyu-Yong (College of Pharmacy, Chungnam National University)
  • 발행 : 2006.08.25
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초록

The purpose of this study is to prepare black ginseng and evaluate its antitumor activity. In order to achieve such aim, 5 year fresh ginsenges were steamed at 95'E for 3 hr in pottery apparatus and dried at $60^{\circ}C$ for 12-36 hr. This process was repeated again nine times in same condition. Among the ginseng saponins in black ginseng, the amount of Ginsenoside $Rg_3$ was examined by HPLC. 10.05 mE of Ginsenoside $Rg_3$ was obtained from 1 g of dried black ginseng prepared. The extract of black ginseng exhibited stronger cytotoxic activity against MCF-1, HT-1080 and Hepa 1C1C7 tumor cell lines in vitro than the extract of red ginseng. Also, the extract of black ginseng exhibited stronger antitumor activity(33%) in BDFl mice bearing Lewis lung carcinoma cells(LLC) than the extract of red ginseng(23%). From these results, it was concluded that Black ginseng had antitumor activity suggesting its application for the prevention and treatment of cancer.

키워드

참고문헌

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