Bioinformatics and Biosystems
- Volume 1 Issue 1
- /
- Pages.61-66
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- 2006
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- 1738-9798(pISSN)
MLP: Mate-based Sequence Layout with PHRAP
- Kim, Jin-Wook (School of Computer Science and Engineering, Seoul National University) ;
- Roh, Kang-Ho (School of Computer Science and Engineering, Seoul National University) ;
-
Park, Kun-Soo
(School of Computer Science and Engineering, Seoul National University)
;
- Park, Hyun-Seok (Macrogen) ;
- Seo, Jeong-Sun (Macrogen)
- Published : 2006.02.28
Abstract
We propose a new fragment assembly program MLP (mate-based layout with PHRAP). MLP consists of PHRAP, repeat masking, and a new layout algorithm that uses the mate pair information. Our experimental results show that by using MLP instead of PHRAP, we can significantly reduce the difference between the assembled sequence and the original genome sequence.
Keywords