Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 16 Issue 1
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- Pages.23-27
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- 2006
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
Validation of a HPLC MS/MS Method for Determination of Doxorubicin in Mouse Serum and its Small Tissues
마우스 혈장과 조직에서의 doxorubicin 측정 HPLC-MS/MS 방법
- Park, Jung-Sun (Department of Pharmacology and Cardiovascular Research Center, Medical School, Chonbuk National University) ;
- Kim, Hye-Kyung (Clinical Trial Center for Functional Foods, Chonbuk Hospital) ;
- Lee, Hye-Won (Clinical Trial Center for Functional Foods, Chonbuk Hospital) ;
- Lee, Mi-Hyun (Clinical Trial Center for Functional Foods, Chonbuk Hospital) ;
- Kim, Hyun-Gi (Department of Pharmacology and Cardiovascular Research Center, Medical School, Chonbuk National University) ;
- Chae, Soo-Wan (Department of Pharmacology and Cardiovascular Research Center, Medical School, Chonbuk National University) ;
- Chae, Han-Jung (Department of Pharmacology and Cardiovascular Research Center, Medical School, Chonbuk National University)
- 박정선 (전북대학교 의과대학 약리학교실 및 심혈관연구소) ;
- 김혜경 (전북대학교병원 기능성식품 임상시험지원센타) ;
- 이혜원 (전북대학교병원 기능성식품 임상시험지원센타) ;
- 이미현 (전북대학교병원 기능성식품 임상시험지원센타) ;
- 김현기 (전북대학교 의과대학 약리학교실 및 심혈관연구소) ;
- 채수완 (전북대학교 의과대학 약리학교실 및 심혈관연구소) ;
- 채한정 (전북대학교 의과대학 약리학교실 및 심혈관연구소)
- Published : 2006.06.30
Abstract
Doxorubicin (DXR) is a type of anti-cancer drug called an 'anthracycline glycoside', It works by impairing DNA synthesis, a crucial feature of cell division, and thus is able to target rapidly dividing cells. Doxorubicin is a very serious anti-cancer medication with definite potential to do great harm as well as great good. A liquid chromatography-tandem mass spectroscopy (LC-MS/MS) method was developed to identify and quantify DXR in small-volume biological samples. After the addition of internal standard (IS,