Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Biological Evaluation of 3-Amino-4-aryl-piperidine Derivatives as BACE 1 Inhibitors

  • Lim, Hee-Jong (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Jung, Myung-Hee (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • ChoiLee, Ihl-Young (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Park, Woo-Kyu (Bio-Organic Science Division, Korea Research Institute of Chemical Technology)
  • Published : 2006.09.20
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Abstract

BACE 1 ($\beta$-secretase), a membrane bound aspartic protease, is a key enzyme in the process of amyloid precursor protein (APP) into A$\beta$ peptide which is considered to play a causative role in Alzheimers Disease (AD). Here, we reported the synthesis and inhibitory activity of optically active 3-amino-4-aryl-piperidines.

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References

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