Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Understanding the RNA-Specificity of HCV RdRp: Implications for Anti-HCV Drug Discovery

  • Kim, Jin-young (Department of Biomedical Science and Technology, Konkuk University) ;
  • Chong, You-hoon (Department of Biomedical Science and Technology, Konkuk University)
  • Published : 2006.01.20
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Abstract

Unlike other viral polymerases, HCV RNA-dependent RNA polymerase (RdRp) has not been successfully inhibited by nucleoside analogues presumably due to its strong substrate specificity for RNA. Thus, in order to understand the RNA-specificity of HCV RdRp, the structural characteristics of the active site was investigated. The hereto unknown 2-OH binding pocket at the active site of RdRp provides invaluable implication for the development of novel anti-HCV nucleoside analogues.

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References

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