Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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A Simple Spectrofluorimetric Method for Determination of Mefenamic Acid in Pharmaceutical Preparation and Urine

  • Tabrizi, Ahad Bavili (Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences)
  • Published : 2006.08.20
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Abstract

A simple, sensitive and rapid spectrofluorimetric method was developed for determination of mefenamic acid in pharmaceutical preparation and human urine. The procedure is based on the oxidation of mefenamic acid with cerium (IV) to produce cerium (III), and its fluorescence was monitored at 354 nm after excitation at 255 nm. The variables affecting oxidation of drug were studied and optimized. Under the experimental conditions used, the calibration graphs were linear over the range 0.03-1.5 mg $L^{-1}$. The limit of detection was 0.009 mg $L^{-1}$ and the relative standard deviation for 5 replicate determinations of mefenamic acid at 1.0 mg $L^{-1}$ concentration level was 1.72%. Good recoveries in the range of 102-107 and 102-109% were obtained for pharmaceutical preparation and human urine, respectively. The proposed method was applied to the determination of MF in one pharmaceutical preparation and human urine. The amounts of mefenamic acid found are very similar to those obtained by a standard method.

Keywords

References

  1. Espinosa-Mansilla, A.; Mumnoz de la Pena, A.; Canada-Canada, F.; Gonzalez-Gomez, D. Anal. Biochem. 2005, 37, 275
  2. Cakyrer, O.; Kylyc, E.; Atakol, O.; Kenar, A. J. Pharm. Biomed. Anal. 1999, 20, 19 https://doi.org/10.1016/S0731-7085(98)00044-2
  3. Maron, M.; Wright, G. J. Pharm. Biomed. Anal. 1990, 8, 101 https://doi.org/10.1016/0731-7085(90)80014-G
  4. Aboul Khier, A.; El-Sadek, M.; Baraka, M. Analyst 1987, 112, 1399 https://doi.org/10.1039/an9871201399
  5. Dinc, E.; Yucesoy, C.; Onur, F. J. Pharm. Biomed. Anal. 2002, 28, 1091 https://doi.org/10.1016/S0731-7085(02)00031-6
  6. Arnaud, N.; Georges, J. Anal. Chim. Acta 2003, 467, 149
  7. Aly, F. A.; Al-Tamimi, S. A.; Alwarthan, A. A. Anal. Chim. Acta 2000, 416, 87 https://doi.org/10.1016/S0003-2670(00)00855-2
  8. Perez-Ruiz, T.; Martinez-Lozano, C.; Sanz, A.; Bravo, E. J. Chromatogr. B 1998, 708, 249 https://doi.org/10.1016/S0378-4347(97)00674-9
  9. Polasek, M.; Pospisilova, M.; Urbanek, M. J. Pharm. Biomed. Anal. 2000, 23, 135 https://doi.org/10.1016/S0731-7085(00)00283-1
  10. Hilton, M. J.; Thomas, K. V. J. Chromatogr. A 2003, 1015, 129 https://doi.org/10.1016/S0021-9673(03)01213-5
  11. Rouini, M. R.; Asadipour, A.; Hoseinzadeh, Y.; Aghdasi, F. J. Chromatogr. B 2004, 800, 189 https://doi.org/10.1016/j.jchromb.2003.09.063
  12. Sun, Y.; Takabe, K.; Kido, H.; Nakashima, M. N.; Nakashima, K. J. Pharm. Biomed. Anal. 2003, 30, 1611 https://doi.org/10.1016/S0731-7085(02)00549-6
  13. Mikami, E.; Goto, T.; Ohno, T.; Matsumoto, H.; Inagaki, K.; Ishihara, H.; Nishida, M. J. Chromatogr. B 2000, 744, 81 https://doi.org/10.1016/S0378-4347(00)00233-4
  14. Hirai, T.; Matsumoto, S.; Kishi, I. J. Chromatogr. B 1997, 692, 375 https://doi.org/10.1016/S0378-4347(96)00509-9
  15. Albero, M. I.; Sanchez-Pedreño, C.; Garcia, M. S. J. Pharm. Biomed. Anal. 1995, 13, 1113 https://doi.org/10.1016/0731-7085(95)01519-Q
  16. Sabry, S. M. Anal. Chim. Acta 1998, 367, 41 https://doi.org/10.1016/S0003-2670(98)00172-X
  17. Capitan-Vallvey, L. F.; Navas, N.; Consonni, M. V.; Todeschini, R. Talanta 2000, 52, 1069 https://doi.org/10.1016/S0039-9140(00)00474-4
  18. Perez Ruiz, T.; Martinez Lozano, C.; Tomas, V.; Carpena, J. Talanta 1998, 47, 537 https://doi.org/10.1016/S0039-9140(98)00086-1
  19. Khashaba, P. Y. J. Pharm. Biomed. Anal. 2002, 27, 923 https://doi.org/10.1016/S0731-7085(01)00609-4
  20. Mohamed, F. A.; Mohamed, H. A.; Hussein, S. A.; Ahmed, S. A. J. Pharm. Biomed. Anal. 2005, 39, 139 https://doi.org/10.1016/j.jpba.2005.03.024
  21. British Pharmacopoeia; HM Stationary Office, 1998
  22. Miller, J. C.; Miller J. N. Statistics for Analytical Chemistry; Wiley: New York, 1984

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