Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of New Anthracycline Derivatives Containing Lactic or Stearic Acid Moiety

  • Rho, Young S. (Department of Chemistry, Chonbuk National University) ;
  • Kim, Wan-Joong (Department of Chemistry, Chonbuk National University) ;
  • Yoo, Dong-Jin (Department of Chemistry, Seonam University)
  • Published : 2006.09.20
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Abstract

Novel anthracycline analogues 2-9 as potential anticancer agents were synthesized from daunomycin (1a) and doxorubicin (1b). Compounds 2, 6, and 7 were prepared by the nucleophilic displacement type esterification of a 14-bromodaunomycin (1c) with a sodium lactate, and stearic acid, respectively. Compounds 3-5 and 7-9 were prepared by the reaction of either daunomycin (1a) or doxorubicin (1b) with L-lactic and stearic acids in the presence of EDCI/PP reagents.

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