Journal of Korean Society for Clinical Pharmacology and Therapeutics (임상약리학회지)
- Volume 14 Issue 1
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- Pages.33-41
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- 2006
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- 1225-5467(pISSN)
Pharmacokinetic Comparison of Two Different Salt Forms of Amlodipine, Amlodipine Orotate and Amlodipine Besylate
Amlodipine의 두 가지 다른 염형태인 Amlodipine Orotate 및 Amlodipine Besylate의 약동학적 특성에 관한 비교 연구
- Tae, Yu-Mi (Department of Pharmacology and Clinical Pharmacology Unit, Seoul National University College of Medicine and Hospital) ;
- Lee, Kyung-Hoon (Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine/Clinical Trial Center, Clinical Research Institute, Samsung Medical Center)
- Published : 2006.06.30
Abstract
This randomized, single-blind, two-sequence, two-period crossover study in 24 healthy volunteers with a 2-week washout interval compared pharmacokinetics of two salt forms of amlodipine formulations, the newly developed formulation (amlodipine orotate,
Keywords
- Amlodipine orotate;
- Amlodipine besylate;
- Pharmacokinetics;
- Salt form;
- Liquid chromatography-tandem mass spectromeoy (LC-MS-MS)