생물정신의학 (Korean Journal of Biological Psychiatry)
- 제12권2호
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- Pages.189-195
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- 2005
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
자살 시도자에서 혈장 Brain-Derived Neurotrophic Factor 농도 저하
Decreased Concentration of Plasma Brain-Derived Neurotrophic Factor in Suicide Attempters
- 원성두 (고려대학교 의과대학 정신과학교실) ;
- 심세훈 (순천향대학교 의과대학 천안병원 정신과학교실) ;
- 양종철 (전남대학교 의과대학 정신과학교실) ;
-
이헌정
(고려대학교 의과대학 정신과학교실) ;
- 이분희 (고려대학교 의과대학 정신과학교실) ;
-
한창수
(고려대학교 의과대학 정신과학교실) ;
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김계현
(성균관대학교 의과대학 강북삼성병원 산부인과학교실) ;
- 김용구 (고려대학교 의과대학 정신과학교실)
- Won, Seong-Doo (Department of Psychiatry, College of Medicine, Korea University) ;
- Shim, Se-Hoon (Department of Psychiatry, Soonchunhyang University CheonAn Hospital) ;
- Yang, Jong-Chul (Department of Psychiatry, Chonnam University Hospital) ;
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Lee, Heon-Jeong
(Department of Psychiatry, College of Medicine, Korea University) ;
- Lee, Bun-Hee (Department of Psychiatry, College of Medicine, Korea University) ;
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Han, Chang-Su
(Department of Psychiatry, College of Medicine, Korea University) ;
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Kim, Kye-Hyun
(Department of Obstetrics and Gynecology, KangBuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
- Kim, Yong-Ku (Department of Psychiatry, College of Medicine, Korea University)
- 발행 : 2005.11.30
초록
Objects:Some studies have suggested that brain-derived neurotrophic factor(BDNF), one of the most important neurotrophins, is involved in pathophysiology of depression and suicide. This study was performed to determine whether there is an abnormality in plasma BDNF concentration in suicidal attempters. Methods:The subjects were 71 suicidal attempters who visited emergency rooms in multi-medical centers. All subjects had been interviewed by using Structured Clinical Interview for DSM-IV(SCID), Hamilton Depression Rating Scale(HDRS), Young Mania Rating Scale(YMRS), and Positive And Negative Syndrome Scale(PANSS). The severity of the suicidal behavior was measured by Lethality of Suicide Attempt Rating Scale(LSARS) and Risk-Rescue Rating(RRR) system. Seventy-one age, sex, and diagnosis matched non-suicidal psychiatric patients who were consecutively admitted to a psychiatric ward during the same period recruited as psychiatric controls. They were drug-naive or drug-free at least more than 2 months. In addition, 80 healthy controls were randomly selected as normal controls. Plasma BDNF level was measured by the enzyme linked immunosorbent assay(ELISA) methods. Results:In overall F-test, differences of the plasma BDNF levels among the groups were statistically significant(F=20.226, p<0.001). In the multiple comparisons(Scheffe), while mean levels of plasma BDNF between normal controls and non-suicidal psychiatric patients were similar(p=0.984), the BDNF levels of suicidal attempters were lower than those of other two groups(p<0.001). LSARS and RRR did not reveal any significant correlations with BDNF levels in suicidal attempters. Conclusion:These results suggest that reduction of plasma BDNF level is related to suicidal behavior and BDNF level may be a biological marker of suicidal behavior.