Journal of Animal Science and Technology

Korean Society of Animal Sciences and Technology (한국축산학회)
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Association Between MSTN Gene Polymorphism and Growth Traits in Landrace Pigs

돼지 Landrace 품종에서 Myostatin 유전자의 유전적 다형성과 성장형질과의 연관성

  • Cho, I.C. (National Institute of Subtropical Agriculture, R.D.A.) ;
  • Choi, Y.L. (National Institute of Subtropical Agriculture, R.D.A.) ;
  • Ko, M.S. (National Institute of Subtropical Agriculture, R.D.A.) ;
  • Kim, H.S. (Division of Applied Life Science, Gyeongsang National University) ;
  • Lee, J.G. (Division of Applied Life Science, Gyeongsang National University) ;
  • Jeon, J.T. (Division of Applied Life Science, Gyeongsang National University) ;
  • Han, Sang-Hyun (National Institute of Subtropical Agriculture, R.D.A.)
  • 조인철 (농촌진흥청 난지농업연구소) ;
  • 최유림 (농촌진흥청 난지농업연구소) ;
  • 고문석 (농촌진흥청 난지농업연구소) ;
  • 김효선 (경상대학교 응용생명과학부) ;
  • 이정규 (경상대학교 응용생명과학부) ;
  • 전진태 (경상대학교 응용생명과학부) ;
  • 한상현 (농촌진흥청 난지농업연구소)
  • Published : 2005.04.30
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Abstract

Porcine myostatin(MS1N) gene plays a key role in the differentiation of myoblast and muscle development. Genetic polymorphism was screened by single stranded conformation polymorphism(SSCP) analysis and subsequent DNA sequencing detected a nucleotide substitution(C2150T) in exon 3 of MSIN gene. Phenotypic association of the polymorphism was tested in a Landrace population and positive effects of the allele T for lean growth traits were found in the population. Even though it is not significant, the pigs have IT and TC genotypes were heavier for the body weight at birth and at twenty weeks of age than those containing genotype. Cc. However, the allele T was significantly associated with higher eye muscle area(P < 0.05). As a result of this study, we suggested that the allele T in exon 3 of MSTN gene comes a significant effect for increasing the eye muscle area without decreasing backfat thickness. This polymorphism did not change the amino acid but Taq I -RFLP matched to SSCP band patterns in exon 3 of MSTN gene, which will be an useful molecular marker for breeding of Landrace pigs.

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References

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