Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Inhibitory Activity of Isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase

  • Oh Hyun Mi (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kwon Byoung-Mog (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Baek Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University) ;
  • Kim Sung-Hoon (Graduate School of East-West Medical Science, KyungHee University) ;
  • Chung In-Sik (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University) ;
  • Park Mi-Hyun (Erom Life Co. Ltd.) ;
  • Park Hee Wook (College of Pharmacy, Woosuk University) ;
  • Lee Jae Hyeok (College of Pharmacy, Woosuk University) ;
  • Park Hye Won (College of Pharmacy, Woosuk University) ;
  • Kim Eun Jeong (College of Pharmacy, Woosuk University) ;
  • Kim Dae Keun (College of Pharmacy, Woosuk University)
  • Published : 2005.02.01
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Abstract

The methanolic extract of the aerial parts of Persicaria thunbergii was found to show inhibitory activity on Farnesyl Protein Transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of isorhamnetin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the $IC_{50}$ value of isorhamnetin was $37.5\;{\mu}M$.

Keywords

References

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