Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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The Inhibition of Diacylglycerol Acyltransferase by Terpenoids from Youngia koidzumiana

  • Dat Nguyen Tien (College of Pharmacy, Chungnam National University) ;
  • Cai Xing Fu (College of Pharmacy, Chungnam National University) ;
  • Rho Mun-Chual (Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee Hyun Sun (Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Bae KiHwan (College of Pharmacy, Chungnam National University) ;
  • Kim Young Ho (College of Pharmacy, Chungnam National University)
  • Published : 2005.02.01
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Abstract

The EtOAc extract of Youngia koidzumiana significantly inhibited the diacylglycerol acyltransferase (DGAT) from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of nine compounds, the structures of which were established using physicochemical and spectral data. Of the isolated compounds, oleanolic acid (2), methyl ursolate (7) and corosolic aicd (8) inhibited DGAT, with $IC_{50}$ values of 31.7, 26.4, and $44.3{\mu}M$, respectively. However, sesquit-erpenoids showed only weak inhibitory effects toward DGAT.

Keywords

References

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