YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

A Ginseng Saponin Induces Production of Nitric Oxide in Macrophages

인삼사포닌에 의한 대식세포 일산화질소 생성 유도

  • Kim Ji Yeon (College of Pharmacy, Sookmyung Women's University) ;
  • Lee Hwa Jin (College of Pharmacy, Sookmyung Women's University) ;
  • Kim Ji Sun (College of Pharmacy, Sookmyung Women's University) ;
  • Ahn Hanna (College of Pharmacy, Sookmyung Women's University) ;
  • Ryu Jae-Ha (College of Pharmacy, Sookmyung Women's University)
  • 김지연 (숙명여자대학교 약학대학) ;
  • 이화진 (숙명여자대학교 약학대학) ;
  • 김지선 (숙명여자대학교 약학대학) ;
  • 안한나 (숙명여자대학교 약학대학) ;
  • 류재하 (숙명여자대학교 약학대학)
  • Published : 2005.02.01
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Abstract

Ginseng root is an important remedy in oriental countries, which has been used for thousands of years. Saponins of ginseng root has been known to be the major component which mediate diverse pharmacological actions of the ginseng. Heat processing of ginseng root potentiates its biological activity such as anti-tumor and anti-oxidative activities. The butanol fraction of heat-processed ginseng (HGB) induced the production of nitric oxide in macrophages in a dose-dependent manner with IFN-${\gamma}$(30 U/ml) priming. The active component was identified as ginsenoside-$Rg_5$ from the activity-guided purification. Ginsenoside $Rg_5$ is one of major components of heat-processed ginseng and red ginseng that is responsible for the potentiated biological activities of processed ginseng. The induction of NO production by heat-processed ginseng might contribute to the potentiated biological activity of heat-processed ginseng.

Keywords

References

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