Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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A Result and Prognostic Factors of Hypofractionation Radiation Therapy in Early Glottic Cancer

초기 성문암 환자에서 소분할조사법의 방사선 치료 결과와 예후 인자

  • Lee Mi-Jo (Department of Radiation Oncology, College of Medicine, Inha University) ;
  • Kim Hun-Jung (Department of Radiation Oncology, College of Medicine, Inha University) ;
  • Kim Woo-Chul (Department of Radiation Oncology, College of Medicine, Inha University) ;
  • Loh Jun-Gou (Department of Radiation Oncology, College of Medicine, Inha University)
  • 이미조 (인하대학교 의과대학 방사선종양학과학교실) ;
  • 김헌정 (인하대학교 의과대학 방사선종양학과학교실) ;
  • 김우철 (인하대학교 의과대학 방사선종양학과학교실) ;
  • 노준규 (인하대학교 의과대학 방사선종양학과학교실)
  • Published : 2005.11.01
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Abstract

Purpose: The purpose of this study was to establish general guidelines for the treatment of patients with early glottic cancer(T1-2N0M0), by assessing the role of primary radiation therapy and by analyzing the tumor-related and treatment-related factors that influence treatment results. We also studied the results of hypofractionated radiation therapy for early glottic cancer. Material and Methods: This retrospective study comprised 48 patients who suffered from early glottic cancer and were treated by primary radiotherapy at Inha University Hospital, between May 1997 and October 2004. T-stage distribution showed 38 patients as T1 and 10 patients as stage T2. Thirty-eight patients underwent hypofractionated radiotherapy using a 6 MY photon beam, a total tumor dose of 63Gy, in 5 weekly fractions of 2.25Gy, with an overall radiation treatment time of 38 days. Ten patients in the T2 stage tolerated a total dose of 63-72 Gy(median 68.4Gy) in 5 weekly fractions of 1.8-2.0Gy, with an overall radiation treatment time of 40-87 days(median 51 days). All patients were followed up for at least 3 years. Univariate and multivariate analyses were performed to identify the prognostic factors affecting the treatment results. Result: The 5-year survival rate was 92% for all patients, 94% for T1 patients and 91% for T2 patients. The local control rate was 93.5% for all patients, 95% for T1 and 92.2% for T2 patients. Three patients suffered a relapse following radiotherapy, and underwent subsequent salvage surgery. We included T-stage, tumor location, total radiation dose, field size and overall radiation treatment time as potential prognostic factors. Only T-stage was found to be statistically significant in the univariate analysis, but in the multivariate analysis, it was not found to be significant. Conclusion: High curative and voice preservation rates were obtained with hypofractionated radiotherapy. Further study with a larger number of patients is needed to determine the prognostic factors affecting treatment results.

Keywords

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