Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Clinical Significance of the Expression of c-Met in Thyroid Tumor

갑상선 종양에서 c-Met 발현의 임상적 의의

  • Rho Young-Soo (Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Hallym University) ;
  • Hwang Joon-Sik (Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Hallym University) ;
  • Kim Jin-Hwan (Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Hallym University) ;
  • Lim Young-Han (Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Hallym University) ;
  • Kim Seung-Tae (Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Hallym University) ;
  • Cho Seong-Jin (Department of Pathology, College of Medicine, Hallym University)
  • 노영수 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 황준식 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김진환 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 임영한 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김승태 (한림대학교 의과대학 이비인후-두경부외과학교실) ;
  • 조성진 (한림대학교 의과대학 병리학교실)
  • Published : 2005.05.01
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Abstract

Objectives: The hepatocyte growth factor(HGF)/c-Met pathway may play various roles in the carcinogenesis of various organs. Although HGF/c-Met signalling pathway has been shown to demonstrate various cellular responses including mitogenic, proliferative, morphogenic and angiogenic activities, the study on their expression related to clinicopathological parameters in thyroid tumor is relatively rare. So we want to find out the clinical significance of the c-Met in thyroid tumor. Materials and Methods: We assess the mRNA and protein expression of the c-Met genes by means of RT-PCR method and the immunohistochemical stain in 100 cases of thyroid tumors(50 papillary carcinomas, 10 follicular carcinomas, 20 follicular adenomas, 20 nodular hyperplasia). Results: By RT-PCR, c-Met mRNA was detected in 43(86%) in papillary carcinoma, 4(40%) in follicular carcinoma, 4(20%) in follicular adenoma and 2(10%) in nodular hyperplasia cases. By immunohistochemistry, c-Met protein expression was detected in 44(88%), 2(20%), 3(15%) and 1(5%). Expression of the c-Met mRNA and protein expression was significantly highly recognized in papillary carcinoma. The c-Met protein overexpression was significantly correlated with the grade of the differentiation. Conclusion: These results suggest that c-Met expression may be associated with thyroid papillary cancer progression. The differential expression of c-Met protein and mRNA suggests that these molecules may be a reliable diagnostic marker in thyroid papillary cancer.

Keywords

References

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