Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Correlations of Oral Tongue Cancer Invasion with Matrix Metalloproteinases(MMPs) and Vascular Endothelial Growth Factor(VEGF) Expression

Matrix Metalloproteinases(MMPs) 및 Vascular Endothelial Growth Factor(VEGF)의 발현을 통한 구강 설암의 침윤 기전 연구

  • Kim Se-Heon (Department of Otorhinolaryngology, Yonsei University College of Medicine) ;
  • Cho Nam-Hoon (Department of Pathology, Yonsei University College of Medicine) ;
  • Lim Jae-Yul (Department of Otorhinolaryngology, Yonsei University College of Medicine) ;
  • Kim Ji-Hoon (Department of Otorhinolaryngology, Yonsei University College of Medicine) ;
  • Kim Jeong-Hong (Department of Otorhinolaryngology, Yonsei University College of Medicine) ;
  • Chang Jung-Hyun (Department of Otorhinolaryngology, Yonsei University College of Medicine) ;
  • Choi Eun-Chang (Department of Otorhinolaryngology, Yonsei University College of Medicine)
  • 김세헌 (연세대학교 의과대학 이비인후과학교실) ;
  • 조남훈 (연세대학교 의과대학 병리학교실) ;
  • 임재열 (연세대학교 의과대학 이비인후과학교실) ;
  • 김지훈 (연세대학교 의과대학 이비인후과학교실) ;
  • 김정홍 (연세대학교 의과대학 이비인후과학교실) ;
  • 장정현 (연세대학교 의과대학 이비인후과학교실) ;
  • 최은창 (연세대학교 의과대학 이비인후과학교실)
  • Published : 2005.05.01
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Abstract

Purpose: In oral tongue cancer, the degree of tumor invasion has a significant effect on the prognosis. We hypothesized that the destruction of extracelluar matrix and neovascularization are related to tumor infiltration mechanism. By studying the the tissues of early stage oral tongue cancer patients, we are intend to clarify the invasion related factors in oral tongue cancer. Material and Methods: To demonstrate the invasion process in early T-stage oral tongue cancer, the expressions of extracellular matrix destruction related molecules(MMP2, MMP9) and neovascularization related molecule(VEGF) were observed by immunohistochemical study. Also, immunohistochemical staining of CD31 was done for quantification of neovascularization. With the experiment showed above, we analyzed relationship between expression of each substances and tumor invasion depth, tumor free survival rates and cervical lymph node metastasis rate in early T-stage oral tongue cancer. Results: The expression rates of MMP2, MMP9, VEGF in 38 early oral cancer patients were 52.6%, 78.9% 52.6%, respectively. Significant correlation was found between the VEGF expression and microvessel density showed by CD31 immunohistochemical staining(p<0.001). VEGF expressions were significantly related with tumor invasion depth(p=0.002). The tumor free survival rate of those patients with VEGF-positive tumors was significantly poorer than in those with VEGF-negative tumors(p=0.019). Conclusion: This results indicate that VEGF is a useful marker for predicting the tumor invasion in patients with early tongue cancer and could be used as a beneficial factors in defining operative field and prognosis.

Keywords

References

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