Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Polymorphisms of Angiotensin-converting Enzyme Gene Associated in Patients with COPD with or without Bronchial Hyperresponsiveness

만성폐쇄성폐질환에서 ACE 유전자 다형성과 기관지 과민성의 연관성

  • Kim, Seung Soo (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Choi, Eu Gene (Department of Internal Medicine, College of Medicine, Konyang University) ;
  • Park, Seoung Ju (Department of Internal Medicine, Medical School and Research Institute of Clinical Medicine, Chonbuk National University) ;
  • Lee, Heung Bum (Department of Internal Medicine, Medical School and Research Institute of Clinical Medicine, Chonbuk National University) ;
  • Lee, Yong Chul (Department of Internal Medicine, Medical School and Research Institute of Clinical Medicine, Chonbuk National University) ;
  • Rhee, Yang Keun (Department of Internal Medicine, Medical School and Research Institute of Clinical Medicine, Chonbuk National University)
  • 김승수 (가톨릭대학교 의과대학 내과학교실) ;
  • 최유진 (건양대학교 의과대학 내과학교실) ;
  • 박성주 (전북대학교 의과대학 내과학교실, 임상의학연구소) ;
  • 이흥범 (전북대학교 의과대학 내과학교실, 임상의학연구소) ;
  • 이용철 (전북대학교 의과대학 내과학교실, 임상의학연구소) ;
  • 이양근 (전북대학교 의과대학 내과학교실, 임상의학연구소)
  • Received : 2004.09.22
  • Accepted : 2004.11.04
  • Published : 2005.01.30
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Abstract

Background : An insertion-deletion polymorphism of angiotensin converting enzyme (ACE) gene has been shown to be associated with enzyme activity levels of ACE. Reported results that have been mutually contradictory about asthmatic hypersensitiveness and occurrence according to ACE gene insertion (I)/deletion (D) polymorphism. Also, the involvement of the ACE genes as the genetic basis of bronchial asthma is currently controversy. We investigated whether there was any association between polymorphisms of the ACE genes and airway hyper-responsiveness in chronic obstructive pulmonary disease (COPD). Methods : A total of 100 patients with COPD were enrolled in this study. The ACE genotypes were determined in all subjects by polymerase chain reaction. Pulmonary function test including bronchodilator response (BDR), methacholine bronchial provocation test (MBPT) were done in those patients. Airway hyper-responsiveness include any findings of positive BDR or MBPT. Results : In COPD patients, the ACE genotype distribution did not differ significantly among groups of patients with severities of COPD, and with or without airway hyper-responsiveness. Conclusions : These results suggest that polymorphisms of the ACE gene may not be associated with airway hyper-responsiveness, development and severity of COPD.

목 적 : ACE 유전자 다형성에 따라 폐를 포함한 여러 조직에서 ACE 활성 및 농도 등에 차이를 나타내고 이러한 차이가 COPD 등의 만성 호흡기 질환에서 질환의 발생 및 임상 표현형의 차이를 유발할 것으로 추정되어 지고 있다. 따라서 이 연구는 ACE 유전자 다형성이 COPD 환자에게서 동반될 수 있는 기도 과민반응 등의 기관지 천식 요소의 발현 유무와 연관성이 있는지 알아보고자 하였다. 방 법 : 100명의 COPD 환자들을 대상으로 기도 과민성의 동반 유무에 따라 두 군으로 분류하였고, PCR 방법을 통하여 ACE 유전자형을 검사하여 두 군 간의 차이를 알아보았다. 결 과 : COPD 환자에서 기도 과민반응 유무에 따른 ACE 유전자형의 분포에 차이는 없었고, COPD의 임상적 단계에 따른 각 군 간의 의미 있는 차이도 보이지 않았다. 결 론 : 이러한 연구 결과는 ACE 유전자 다형성에 따른 차이가 COPD 환자에게서 나타나는 기도 과민성 등의 천식 요소의 발현과 연관이 없음을 시사하는 소견이라 할 수 있다.

Keywords

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