Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Progressive Lung Involvement during Steroid Therapy in Idiopathic Hypereosinophilic Syndrome

특발성 과호산구 증후군에서 스테로이드 투약 중 진행한 폐침윤 1례

  • Park, Ji Young (Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Choi, Ju Young (Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Jung, Ji Min (Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Sim, Yun Su (Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Pyun, Gun Woo (Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Na, Youn Ju (Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Kang, Min Jung (Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Kang, In Sook (Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Lee, Si Nae (Department of Pathology, College of Medicine, Ewha Womans University) ;
  • Kim, Yookyung (Department of Diagnostic Radiology of Medicine, College of Medicine, Ewha Womans University) ;
  • Jeong, Jee-Hyong (Department of Neurology, College of Medicine, Ewha Womans University) ;
  • Lee, Jin Hwa (Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Cheon, Eun Mee (Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Chang, Jung Hyun (Department of Internal Medicine, College of Medicine, Ewha Womans University)
  • 박지영 (이화여자대학교 의과대학 내과학교실) ;
  • 최주영 (이화여자대학교 의과대학 내과학교실) ;
  • 정지민 (이화여자대학교 의과대학 내과학교실) ;
  • 심윤수 (이화여자대학교 의과대학 내과학교실) ;
  • 변건우 (이화여자대학교 의과대학 내과학교실) ;
  • 나윤주 (이화여자대학교 의과대학 내과학교실) ;
  • 강민정 (이화여자대학교 의과대학 내과학교실) ;
  • 강인숙 (이화여자대학교 의과대학 내과학교실) ;
  • 이시내 (이화여자대학교 의과대학 병리학교실) ;
  • 김유경 (이화여자대학교 의과대학 방사선과학교실) ;
  • 정지향 (이화여자대학교 의과대학 신경내과학교실) ;
  • 이진화 (이화여자대학교 의과대학 내과학교실) ;
  • 천은미 (이화여자대학교 의과대학 내과학교실) ;
  • 장중현 (이화여자대학교 의과대학 내과학교실)
  • Received : 2005.04.04
  • Accepted : 2005.07.04
  • Published : 2005.07.30
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Abstract

Hypereosinophilic syndrome (HES) is characterized by a sustained eosinophilia of $1,500/mm^3$ or more in the absence of any known causes or the signs and symptoms of organ involvement. We report a 64-year-old man with HES initially presenting with involvement of the liver and bone marrow. Despite controlling the eosinophilia by corticosteroid, he developed a cerebral infarction and later progressive interstitial pneumonia. Brain angiography revealed a severe stenosis of the proximal right internal carotid artery (ICA) and a complete obstruction of the intracranial ICA. An open lung biopsy revealed fibrosis and lymphoplasma cell infiltration without eosinophils, which were consistent with nonspecific interstitial pneumonia.

저자들은 골수와 간을 침범하여 스테로이드 치료 후 말초 호산구수가 감소하고 증상이 호전되었으나, 뇌경색이 발생하고 폐침윤이 진행하고 있는 특발성과 호산구증후군 1례를 경험하였기에 문헌고찰과 함께 보고한다.

Keywords

References

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