Journal of Haehwa Medicine (혜화의학회지)
- Volume 14 Issue 2
- /
- Pages.45-54
- /
- 2005
- /
- 2586-3002(pISSN)
- /
- 2586-3347(eISSN)
Suppressive Effects of GST on Cytokine-induced Activation of Human Fibroblast-like Sinoviocytes
가미사물탕(GST)의 사이토카인으로 유도된 인간 섬유아세포양 활막 세포 활성화 저해 작용
- Park, Jee-Young (Dept. of Pathology, College of Oriental Medicine, Daejeon University) ;
-
Jin, Mi-Rim
(Dept. of Pathology, College of Oriental Medicine, Daejeon University) ;
-
Kim, Dong-Hee
(Dept. of Pathology, College of Oriental Medicine, Daejeon University)
- Accepted : 2005.11.21
- Published : 2005.12.31
Abstract
GST, an extract from 16 herbs, has been formulated and prescribed for the treatment of human rheumatoid arthritis(hRA) for many years. The present study was done to investigate whether GST has suppressive effects on activation of fibroblast-like sinoviocytes isolated from an RA patient. In tumor necrosis factor-a(TNF-a)/interleukin-1b(IL-1b) treated human sinoviocytes, The mRNA expression of molecular indicators related to pathologic changes of the sinoviocytes were examined using quantitative real-time PCR. The treatment of GST(
Keywords
- GST;
- hRA;
- human fibroblast-like sinoviocytes;
- proinflammatory cytokines;
- IL-8;
- ICAM-1;
- NOS-II;
- NO;
- MMP-3;
- TIMP-1