Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Release of Calcein from Temperature-Sensitive Liposomes in a Poly(N-isopropylacrylamide) Hydrogel

  • Han Hee Dong (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Kim Tae Woo (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Shin Byung Cheol (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Choi Ho Suk (Department of Chemical Engineering, Chungnam National University)
  • Published : 2005.02.01
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Abstract

We prepared temperature-sensitive liposomes (TS-liposomes) modified with a thermo sensitive polymer, such as poly(N-isopropylacrylamide) (PNIPAAm), to increase the degree of drug release from liposomes at the hyperthermic temperature. A PNIPAAm hydrogel containing TS-Iiposomes was also prepared to obtain a hydrogel complex at body temperature. In addition, a depot system for local drug delivery using the polymer hydrogel was developed to enhance therapeutic efficacy and prevent severe side effects in the whole body. The PNIPAAm-mod­ified TS-liposome was fixed into the PNIPAAm hydrogel having a high temperature-sensitivity. The release behavior of calcein, a model drug, from TS-liposomes in the PNIPAAm hydrogel was then initiated by external hyperthermia; the results indicated that sustained release as a function of temperature and time was caused by the thermosensitivity of the liposome surface and diffusion of the drug into the PNIPAAm hydrogel. Our results indicated that TS-liposomes in a PNIPAAm hydrogel represented a plausible system for local drug delivery.

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