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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and Conformational Study of 2-Trityloxymethyltet­rahydrofurans as Key Intermediates for Antiviral Nucleosides

  • Choi Hye-Young (College of Pharmacy, Sookmyung Women's University) ;
  • Kim Hee-Doo (College of Pharmacy, Sookmyung Women's University)
  • Published : 2005.01.01
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Abstract

We wanted to elucidate the reason why the trityloxymethyl substituent in $\gamma$-trityloxymethyl-$\gamma$­butyrolactone takes a sterically unfavorable specific conformation, and so we synthesized 5-trityloxymethyldihydrofuran-3-one, 3-(trityloxymethyl)-4-butanolide and 2-trityloxymethyl- tetrahy­drofuran and we then analyzed their conformation by $^{1}H-NMR$ analysis.

Keywords

References

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