Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
권호 표지

Effect of Scutellariae Radix extract on immune cells in OVA-induced asthmatic mice lung tissue

황금이 천식모델 생쥐의 폐조직내 면역세포에 미치는 영향

  • Park, Gil-Byung (Dept. of Internal Medicine College of Oriental Medicine, Daejeon University) ;
  • Park, Yang-Chun (Dep. of Internal Medicine College of Oriental Medicine, Daejeon University)
  • 박길병 (대전대학교 한의과대학 폐계내과학교실) ;
  • 박양춘 (대전대학교 한의과대학 폐계내과학교실)
  • Accepted : 2005.05.09
  • Published : 2005.06.30
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Abstract

Objective : The purpose of this research is to examine the effects of Scutellariae Radix(SR) extract on immune cells in ovalbumin(OVA)-induced asthmatic mice. Methods : In vitro, C57BL/6 mice were exposed to OVA for 6 weeks. The mice lungs were taken out, chopped, grinded with collagenase and activated by rIL-3/rIL-5. The lung cells were treated with SR extract and analyzed by a flow cytometer. Results : The population of granulocytes/lymphocytes, CD3e-/CCR3+, CD69+/CD3e+, CD23+/B220+, CD4+ cells in the SR group in vitro decreased and population of CD8+ cells in the 100 and $10{\mu}g/m{\ell}$ SR group in vitro decreased, compared with that of control group. Conclusion : The results of this study support a role for SR as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions.

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