Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Seroprevalence of Measles Antibody and its Attributable Factors in Elementary Students of Routine 2-dose Schedule Era with Vaccination Record

예방접종력이 있는 초등학생의 홍역 항체 양성률 및 기여 요인

  • Lim, Hyun-Sul (Department of Preventive Medicine, College of Medicine, Dongguk University) ;
  • Goh, Un-Yeong (Korea Center for Diease Control and Prevention, Ministry of Health and Welfare) ;
  • Yang, Byung-Guk (Korea Center for Diease Control and Prevention, Ministry of Health and Welfare) ;
  • Kim, Young-Taek (Korea Center for Diease Control and Prevention, Ministry of Health and Welfare) ;
  • Lee, Jong-Koo (Korea Center for Diease Control and Prevention, Ministry of Health and Welfare) ;
  • Bae, Geun-Ryang (Department of Preventive Medicine, College of Medicine, Dongguk University)
  • 임현술 (동국대학교 의과대학 예방의학교실) ;
  • 고운영 (보건복지부 질병관리본부) ;
  • 양병국 (보건복지부 질병관리본부) ;
  • 김영택 (보건복지부 질병관리본부) ;
  • 이종구 (보건복지부 질병관리본부) ;
  • 배근량 (동국대학교 의과대학 예방의학교실)
  • Published : 2005.12.01
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Abstract

Objectives : We investigated the seroprevalence of the measles antibody and its at tributable factors for the students who underwent routine 2-dose Schedule Era. Methods : The subjects were 996 students of the national measles seroepidemiologic study in December 2000 who had vaccination records. We conducted a questionnaire survey and we performed serologic testing for the measlesspecific IgG by using an enzyme linked immunosorbent assay. Results : The coverage for the first dose of the MMR vaccination at 12-15 months of age was 95.1% and the coverage for the second dose of MMR at 4-6 years of age was 35.0%. The proportion of subjects undergoing 2-dosesof MMR dec reased as the age of the subjects increased. The seropositive rate of the measles antibody was significantly high in the second dose vaccinees (93.5% in the second dose group, 84.7% in the non-second dose group, p<0.001) and it was 72.0% in the 0-dose group, 85.4% in the 1-dose group and 93.7% in the 2-dose group (p<0.001). Two point eight percent of the subjects had a past history of measles infection. On the multiple logistic regression analysis, the first and second dose (odds ratio, 8.54; 95% CI.=3.05-23.91), the first dose (odds ratio, 3.06; 95% CI.=1.20-7.81) and the outbreak in the year 2000 (odds ratio, 1.89; 95% CI.=1.24-2.88) were the significant factors for the seropositivity. Conclusions : Maintaining high coverage with a 2-dose vaccination program would be the decisive factor to prevent an outbreak of measles and to eliminate measles in Korea.

Keywords

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