Journal of Preventive Medicine and Public Health

  • 제38권2호
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  • Pages.170-174
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  • 2005
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  • 1975-8375(pISSN)
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  • 2233-4521(eISSN)
대한예방의학회 (The Korean Society for Preventive Medicine)
권호 표지

Anti-HBc 단독 양성자에서 B형 간염 백신 접종의 면역 반응과 B형 간염 DNA의 조사

A Study of Immune Response to Hepatitis B Vaccine & HBV DNA in Isolated Anti-HBc Positive Subjects

  • 김순덕 (고려대학교 의과대학 예방의학교실) ;
  • 최지호 (인하대학교 의과대학 가정의학교실) ;
  • 김성열 (인하대학교 의과대학 가정의학교실) ;
  • 이진수 (인하대학교 의과대학 감염내과학교실) ;
  • 고희정 (인하대학교 의과대학 가정의학교실)
  • Kim, Soon-Duck (Department of Preventive Medicine, College of Medicine, Korea University) ;
  • Choi, Ji-Ho (Department of Family medicine, College of Medicine, Inha University) ;
  • Kim, Sung-Ryul (Department of Family medicine, College of Medicine, Inha University) ;
  • Lee, Jin-Soo (Department of Infectious internal medicine, College of Medicine, Inha University) ;
  • Koh, Hee-Jeong (Department of Family medicine, College of Medicine, Inha University)
  • 발행 : 2005.06.01
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초록

Objectives: The aim of this study was to evaluate the response to a hepatitis B vaccination, and investigate the HBV DNA in subjects with isolated anti-HBc. Methods: 34 subjects with persistent isolated anti-HBc were included in the study. 32 subjects negative for HBsAg, anti-HBs and anti-HBc were included as a control group. They were all vaccinated with Hepaccine at 0, 1 and 2 months, and anti-HBs titers were measured 1 month after the 1st and 3rd vaccinations (1 and 3 months). The HBV-DNA was tested by polymerase chain reaction in subjects with isolated anti-HBc. Results: After the 1st & 3rd vaccinations, the anti-HBs titers$\geq$10mIU/ml were 70.6 & 70.6% in isolated anti-HBc group, and 34.4 & 81.2% in the control group, respectively. There were statistically significant differences after the 1st vaccination, but none after the 3rd, between the two groups. In the isolated anti-HBc and control groups, the primary, amnestic and no responses were 0 vs. 46.9%, 55.9 vs. 6.3% and 29.4 vs. 18.8%, respectively. The HBV DNA was not detected in all subjects with isolated anti-HBc. Conclusion: None of the subjects with isolated anti-HBc had a false positive result (primary response); therefore, they should be excluded from vaccination programs in Korea. To differentiate between immunity and occult infections, a single dose of vaccine, with a follow-up anti-HBs test, is preferable for subjects with isolated anti-HBc. An amnestic response indicates late immunity, and no response a suspect occult infection.

키워드

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