The Analysis of Neuro-Physiological Outcome of Patients with Status Epilepticus in an Intensive Care Unit

집중치료실에서 치료한 중첩성 경련 환자의 신경생리학적 결과 분석

  • Kim, Dae-Sik (Department of Clinical Laboratory Science, Dongnam Health College) ;
  • Kim, Cheon-Sik (Department of Clinical Neurosciences, Asan Medical Center)
  • 김대식 (동남보건대학 임상병리과) ;
  • 김천식 (서울아산병원 신경과)
  • Published : 2005.08.31


Status epilepticus is a medical emergency, so that rapid and vigorous treatment is required to prevent neuronal damage and systemic complication. Status epilepticus is generally defined as a continuous or intermittent seizure or an unconscious condition after the onset of seizure, lasting for 30 minutes or more. We report here the outcome of status epilepticus. We retrospectively reviewed medical record of 15 patients who were diagnosed with status epilepticus at the Asan Medical Center from January 2003 to February 2004. This outcome was evaluated considering various factors such as age of patients, history of seizures, neurologic impairment, etiology, mortality, return to baseline and initial electroencephalogram (EEG) findings. The range of age was between 1 to 79 years old and the longest duration of treatment was 118 days. Most patients were treated by using pentobarbital, midazolam, phenobarbital and other antiepileptic drugs. The overall mortality was 5 (33%) out of 15 patients. The mortality was related to etiology, underlying other medical conditions and initial EEG findings. 5 (55%) out of the 9 patients with acute etiology, 5 (71%) out of the 7 patients with a multifocal or burst-suppression EEG activity, and 3 (60%) out of the 5 patients with other medical disease were related to mortality. This data demonstrate high mortality due to status epilepticus. Mortality is related to etiology, other medical conditions and abnormalities on the initial EEG.



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