Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Lipoxygenase Inhibitory Constituents from Indigofera oblongifolia

  • Sharif, Ahsan (International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi) ;
  • Ahmed, Ejaz (International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi) ;
  • Malik, Abdul (International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi) ;
  • Riaz, Naheed (Pharmaceutical Research Center, PCSIR Laboratories Karachi Complex) ;
  • Afza, Nighat (Pharmaceutical Research Center, PCSIR Laboratories Karachi Complex) ;
  • Nawaz, Sarfraz Ahmad (International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi) ;
  • Arshad, Muhammad (International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi) ;
  • Shah, Muhammad Raza (International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi) ;
  • Chaudhary, Muhammad Iqbal (International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi)
  • Published : 2005.07.01
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Abstract

Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with $\beta$-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.

Keywords

References

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