수종의 재생 술식 시행이 매식체 근원심부의 골재생에 미치는 영향

The Effects of various Regeneration techniques on Bone Regeneration around Dental Implant

  • 이명자 (단국대학교 치과대학 치주과학교실) ;
  • 임성빈 (단국대학교 치과대학 치주과학교실) ;
  • 정진형 (단국대학교 치과대학 치주과학교실) ;
  • 홍기석 (단국대학교 치과대학 치주과학교실)
  • Lee, Myung-Ja (Department of Periodontology, College of Dentistry, Dan-Kook University) ;
  • Lim, Sung-Bin (Department of Periodontology, College of Dentistry, Dan-Kook University) ;
  • Chung, Chin-Hyung (Department of Periodontology, College of Dentistry, Dan-Kook University) ;
  • Hong, Ki-Seok (Department of Periodontology, College of Dentistry, Dan-Kook University)
  • 발행 : 2005.06.30

초록

The successful implantation necessitate tissue regeneration m site of future implant placement, there being severe bone defect. Therapeutic approaches to tissue regeneration in the site have used bone grafts, root surface treatments, barrier membranes, and growth factors, the same way being applied to periodontal tissue regeneration. Great interest in periodontal tissue regeneration has lead to research in bone graft, guided-tissue regeneration, and the administration of growth factors as possible means of regenerating lost periodontal tissue. The blood component separated by centrifuging the blood is the platelet-rich plasma. There are growth factors, PDGF, $TGF{beta}1$, $TGF{beta}2$ and IGF in the platelet-rich plasma. The purpose of this study was to study the histopathological correlation between the use of platelet-rich plasma and the healing of bone defect around implant fixture site. Implant fixtures were inserted and graft materials were placed into the left femur of in the experimental group, while the control group received only implant fixtures. In the first experimental group, platelet-rich plasma and BBP xenograft were placed at the implant fixture site, and the second experimental group had platelet-rich plasma, BBP xenograft, and the e-PTFE membrane placed at the fixture site. The degree of bone regeneration adjacent to the implant fixture was observed and compared histopathologically at 2, 4, and 8 weeks after implant fixture insertion. The results of the experiment were as follows: 1. Bone remodeling in acid etched surface near the implant fixture of all experimental groups was found to be greater than new bone formation. 2. Bone remodeling in acid etched surface distant to the implant fixture of all experimental groups was decreased and new bone formation was not changed. 3. Significant new bone formation in machined surface near the implant fixture of bothl experimental groups was observed in 2 weeks. 4. New bone formation in machined surface distant to the implant fixture of both experimental groups was observed. Bone remodeling was significant in near the implant fixture and not in distant to the implant fixture. The results of the experiment suggested that the change of bone formation around implant. Remodeling in machined surface distant to the implant fixture of both experimental groups, and new bone formation and remodeling near the implant fixture were significant.

키워드

참고문헌

  1. Mellonig JT : Autogenous and allogenic bone grafts in periodontal therapy. Crit Rev Oral Biol 1992;3:333-352
  2. Meffert. R.M., Thomas, J,R, ; Hydroxyapatite as an alloplastic grafts in the treatment of human periodontal osseous defects. J Periodontol 1985;56:63-73
  3. Wikesio UME, Baker PJ, Christersson LA, Genco RJ, Lyall RM, Hic S, Diflorio RM. and Terranova, VP. : A biochemical approach to periodontal regeneration : Tetracycline treatment conditions dentin surfaces. J Periodontal Res. 21:322-329, 1986 https://doi.org/10.1111/j.1600-0765.1986.tb01466.x
  4. Garret S, Criger M, and Egelberg J. : Effect of citric acid on diseased root surface. J Periodontal Res 13;155-163, 1978 https://doi.org/10.1111/j.1600-0765.1978.tb00164.x
  5. Fariava H, Salonen J, Hakkinen L, and Narhi T : Effect of citric acid treatment on the migration of epithelium on root surface in vitro. J Periodontol 59;95, 1988
  6. Ririe. CM, Crigger M and Selving KA. : Healing of periodontal connective tissues following surgical wounding and application of citric acid in dogs. J Periodontal Res 15:314-327,1980 https://doi.org/10.1111/j.1600-0765.1980.tb00287.x
  7. Gottlow J, Nyman S : New attachment formation as the result of controlled tissue regeneration. J Clin Periodontol 1984;11;494-503 https://doi.org/10.1111/j.1600-051X.1984.tb00901.x
  8. Caffesse,R.G,Smith, B.A. : New attachment achieved by guided tissue regeneration in the beagle dogs. J Periodontol 1988;59;589-594 https://doi.org/10.1902/jop.1988.59.9.589
  9. Marx RE, Carlson ER, Eichstaedt RH, Schimmele SR, Strauss JE, Georgeff KR: Platelet-rich plasma : Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol 1998;85:638-646 https://doi.org/10.1016/S1079-2104(98)90029-4
  10. Howell TH, Fiorellini JP and Paquette DW : A phase I/II clinical trial to evaluation a combination of recombinant human insulin-like growth factor-I in patients with periodontal disease. J Periodontol 1997;68:1186-1193 https://doi.org/10.1902/jop.1997.68.12.1186
  11. Machtei, E. E., Cho. M. I., Dunford, R., Norderyd, J., Zambon, J. J. & Genco, R, J. : Clinical, microbiological, and histological factors which influence the success of regenerative periodontal therapy. J Periodontol 1994;65:154-161 https://doi.org/10.1902/jop.1994.65.2.154
  12. Caton, J., Greenstein, G. & Zappa, U. : Synythetic bioabsorbable barrier for regeneration in human periodontal defects. J Periodontol 1994;65:1037-1045 https://doi.org/10.1902/jop.1994.65.11.1037
  13. Lu HJ. : Topographical characteristics of root trunk length related to guided tissue regeneration. J Periodontol 1992;63:215-219 https://doi.org/10.1902/jop.1992.63.3.215
  14. Terranova VP, Hick S, Franzetti L, Lyall RM, Wikesso VME. : A biochemical approach to periodontaol regeneration, AFS CM, Assay for specific cell migration. J Periodontol 1987;58:247-259 https://doi.org/10.1902/jop.1987.58.4.247
  15. Terranova VP, Franzetti LC, Hick S, Wikesj VME. : Biochemically mediated periodontal regeneration. J Periodontal Res 1987;22:248-251 https://doi.org/10.1111/j.1600-0765.1987.tb01580.x
  16. Terranova VP, Odziemiec C, Tweden KS, Spadone DP. : Repopulation of dentin surfaces by periodontal ligament cells and endothelial cells. J Periodontol 1989;60:293-301 https://doi.org/10.1902/jop.1989.60.6.293
  17. Lynch SE. Williams RC. Polson AM, Howell TH, Reddy Ms, Zappa UE, Antoniades HN. : A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. J Clin Periodontol 1989;16:545-548 https://doi.org/10.1111/j.1600-051X.1989.tb02334.x
  18. Linch SE, Castillia GR, Williams RC, Kiritry CP, Howell TH, Reddy MS : The effects of short-term application of a combination of platelet-derieved and insulin-like growth factors on periodontal wound healing, J Periodontol 1991;62: 458-467 https://doi.org/10.1902/jop.1991.62.7.458
  19. Deporter DA, Watson PA, Pillar RM. : A histological assessment of the initial healing response adjacent to porous-surface, titanium alloy dental implant system in dogs. J Dent Res. 1986;65:1064-1070 https://doi.org/10.1177/00220345860650080501
  20. Adell R. Lekholm D, Rocker B, Branemark PI. : A 15-year study of Osseointergrated implants in the treatment of the edentulous jaw. Int J Oral Surg. 1981;10:387-416 https://doi.org/10.1016/S0300-9785(81)80077-4
  21. Babbush CA, Kent JN, Misiekm DJ : Titanium plasma sprayed(TPS) screw implants for the reconstruction of the edentulous mandible. J Oral Maxillofac Surg. 1986;44:274-282 https://doi.org/10.1016/0278-2391(86)90078-9
  22. Albrektsson T, Dahl E. Enbom L: Osseointegrated oral implants. A Swedish multicenter study of 8139 consecutively inserted nobelpharma implants. J Periodontol. 1988;59:287-296 https://doi.org/10.1902/jop.1988.59.5.287
  23. Glickman RS, Bae R, Karlis V. : A model to evaluate bone substitutes for immediate implant placement. Implant Dent. 2001;10(3):209-15 https://doi.org/10.1097/00008505-200107000-00016
  24. Lu B, Liu B, Chen X. : Establishment of immediate implant animal model in mongrel dogs fresh extraction socket. Hua Xi Kou Qiang Yi Xue Za Zhi. 1997 Nov: 15(4):319-21
  25. Schultes G, Gaggl A. : Histologic evaluation of immediate versus delayed placement of implants after tooth extraction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jul;92(1):17-22 https://doi.org/10.1067/moe.2001.115464
  26. Nociti Junior FH, Stefani CM, Machado MA, Sallum EA, Toledo S, Sallum AW. : Histometric evaluation of bone regeneration around immediate implants partially in contact with bone: a pilot study in dogs. Implant Dent. 2000;9(4):321-328 https://doi.org/10.1097/00008505-200009040-00007
  27. Alliot B, Piotrowski B, Marin P, Zahedi S, Brunel G. : Regeneration procedures in immediate transmucosal implants: an animal study. Int J Oral Maxillofac Implants. 1999 Nov-Dec;14(6):841-848
  28. Cornelini R, Scarano A, Covani U, Petrone G. Piattelli A. : Immediate onestage postextraction implant: a human clinical and histologic case report. Int J Oral Maxillofac Implants. 2000 May-Jun. 15(3):432-437
  29. Godfredsen K, Nimb L, Hiorting-Hansen E : Immediate implant placement using a biodegradable barrier, polyhydroxybutyrate hydroxyvalerate reinforced with polyglactin 910. Clin Oral Implants Res 1994;5:83-91 https://doi.org/10.1034/j.1600-0501.1994.050204.x
  30. Holmes RE: Bone Regeneration within a Coralline Hydroxyapatite Implant. Plast Reconstr Surg 1979;63:626-633 https://doi.org/10.1097/00006534-197905000-00004
  31. Stahl, S, Frou, S : Histologic and clinical responses to porous hydroxyapatite implants in human periodontal defects. J Periodontol 1987;58:689-695 https://doi.org/10.1902/jop.1987.58.10.689
  32. Dahlin C, Sennerby L. Lekholm D, Linde A, Nyman S. : Generation of new bone around titanium implants using a membrane technique : An experimental study in rabbits. Int J Oral Maxillofac Implants 1989;4:19-25
  33. Becker W, Becker B, Handelsman M, Celleti R, Ochsenbein C, Hardwick R. Langer B : Bone formation at dehisced dental implant sites treated with implant augmentation material : A pilot study in dogs. Int J Periodont Rest Dent 1990;10:93-101
  34. Fugazzotto PA. : Immediate implant placement and GBR in humans: a case report and histologic evaluation. Int J Periodontics Restorative Dent. 1999 Oct: 19(5):457-463
  35. Mao C, Sato J, Matsuura M, Seto K. : Guided tissue regeneration around dental implants in immediate extraction sockets: comparison of resorbable and nonresorbable membranes. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1997 Dec; 19(6): 436-441
  36. Mathys EC. : Immediate implants: indications and clinical decision making : J Colo Dent Assoc. 1998 Autumn;77(4) : 20-25
  37. Mao C, Sato J, Matsuura M, Seto K. : Guided tissue regeneration around dental implants in immediate extraction sockets: comparison of resorbable and nonresorbable membranes. Chin Med Sci J. 1997 Sep;12(3):170-174
  38. Brunel G, Benque E, Elharar F, Sansac C, Duffort JF, Barthet P, Baysse E, Miller N. : Guided bone regeneration for immediate non-submerged implant placement using bioabsorbable materials in Beagle dogs. Clin Oral Implants Res. 1998 Oct:9(5):303-312 https://doi.org/10.1034/j.1600-0501.1998.090503.x
  39. Becker W, Becker B : Guided tissue regeneration for implants placed into extraction sockets and for implant dehiscences : Surgical techniques and case reports. Int J Periodont Rest Dent 1990;10:377-392
  40. Nyman SLang N, Buser D, Bragger U : Bone regeneration adjacent to titanium dental implant using guided tissue regeneration : A report of two cases. Int J Oral Maxillofac Implants 1990;5;9-14
  41. Kohal RJ, Mellas P, Hurzeler MB, Trejo PM, Morrison E, Caffesse RG : The effects of guided bone regeneration and grafting on implants placed into immediate extraction sockets. An experimental study in dogs. J Periodontol. 1998 Aug;69(8) :927-937 https://doi.org/10.1902/jop.1998.69.8.927
  42. Wilson TG Jr, Schenk R, Buser D, Cochran D. : Implants placed in immediate extraction sites: a report of histologic and histometric analyses of human biopsies. Int J Oral Maxillofac Implants. 1998 May-Jun:13(3):333-341
  43. Antonaides HN, Williams LT. : Human platelet-derived growth factor: structure and functions. Federation Proc 1983;42:2630-2634
  44. Bowen-Dope DF, Vogel A, Ross R. : Production of platelet derived growth factor like molecules and reduced expression of platelet derived growth factor receptors accompany transformation by a wide spectrum of agents. Proc Natl Acad Sci USA 1984;81:2396-2400 https://doi.org/10.1073/pnas.81.8.2396
  45. Marx RE, Saunders TR. : Reconstuction and rehabilitation of cancer patients. Reconstuctive Prosthetic Oral and Maxillofacial surgery Philadelphia; Saunders 1986:347-427
  46. Miyazono K, Ten-Dijke P. Ichiyo H, Heldin CH. : Receptors for transforming growth factor-${\beta}$ Immunol 1994;15:181-220
  47. Roberts AB, Spron ME. Physioligical actions and clinical application of transforming growth factor-${\beta}$. Growth factor 1993;8:1-9 https://doi.org/10.3109/08977199309029129
  48. Kassolis JD, Rosen PS, Reynolds MA : Alveolar ridge and sinus augmentation utilizing platelet rich plasma in combination with freeze dried bone allograft : case series. J Periodontol 2000;71:1654-1661 https://doi.org/10.1902/jop.2000.71.10.1654