Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

A study on the safety and efficacy of bovine bone-derived bone graft material(OCS-B)

생체 유래 골 이식재(OCS-B)의 안전성 및 유효성에 관한 연구

  • Park, Ho-Nam (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Han, Sang-Hyuk (NIBEC Inc) ;
  • Kim, Kyoung-Hwa (Department of Periodontology, College of Dentistry, Seoul National University, Intellectual Biointerface Engineering Center, KOSEF) ;
  • Lee, Sang-Chul (NIBEC Inc) ;
  • Park, Yoon-Jeong ;
  • Lee, Sang-Hoon (Department of Dental Biomaterials Sciences, College of Dentistry, Seoul National University, Intellectual Biointerface Engineering Center, KOSEF) ;
  • Kim, Tae-Il (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Seol, Yang-Jo (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Ku, Young (Department of Periodontology, College of Dentistry, Seoul National University, Intellectual Biointerface Engineering Center, KOSEF) ;
  • Rhyu, In-Chul (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Han, Soo-Boo (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Chung, Chong-Pyoung (Department of Periodontology, College of Dentistry, Seoul National University, Intellectual Biointerface Engineering Center, KOSEF)
  • 박호남 (서울대학교 치과대학 치주과학교실) ;
  • 한상혁 ((주) 나이벡) ;
  • 김경화 (서울대학교 치과대학 치주과학교실, 지능형 생체계면공학연구센터, 한국과학재단) ;
  • 이상철 ((주) 나이벡) ;
  • 박윤정 (Craniomaxillofacial Reconstructive Science Major, College of Dentistry, Seoul National University, Intellectual Biointerface Engineering Center, KOSEF) ;
  • 이상훈 (서울대학교 치과대학 치과생체재료과학교실, 지능형 생체계면공학연구센터, 한국과학재단) ;
  • 김태일 (서울대학교 치과대학 치주과학교실) ;
  • 설양조 (서울대학교 치과대학 치주과학교실) ;
  • 구영 (서울대학교 치과대학 치주과학교실, 지능형 생체계면공학연구센터, 한국과학재단) ;
  • 류인철 (서울대학교 치과대학 치주과학교실) ;
  • 한수부 (서울대학교 치과대학 치주과학교실) ;
  • 정종평 (서울대학교 치과대학 치주과학교실, 지능형 생체계면공학연구센터, 한국과학재단)
  • Published : 2005.06.30
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Abstract

Inorganic bovine bone mineral has been widely researched as bone substitution materials in orthopedic and oral and maxillofacial application. OCS-B(NIBEC, Korea) is newly-developed inorganic bovine bone mineral. The aim of this study is to evaluate the safety and efficacy of bovine bone-derived bone graft material(OCS-B). Micro-structure of newly-developed inorganic bovine bone mineral(OCS-B) was analyzed by scanning electron microscope(SEM). Round cranial defects with eight mm diameter were made and filled with OCS-B in rabbits. OCS-B was inserted into femoral quadrant muscle in mouse. In scanning electron microscope, OCS-B was equal to natural hydroxyapatite. Rabbits were sacrificed at 2 weeks and 4 weeks after surgery and mice were sacrificed at 1 week and 2 weeks after surgery. Decalcified specimens were prepared and observed by microscope. In calvarial defects, osteoid and new bone were formed in the neighborhood of OCS-B at 2 weeks after surgery. And at 4 weeks after surgery osteoid and new bone bridge formed flourishingly. No inflammatory cells were seen on the surface of OCS-B at 1 week and 2 weeks in mouse experimental group. It is concluded that newly-developed inorganic bovine bone mineral(OCS-B) is a flourishing bone-forming material and biocompatible material.

Keywords

References

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