한국식품위생안전성학회지 (Journal of Food Hygiene and Safety)

  • 제20권1호
  • /
  • Pages.18-21
  • /
  • 2005
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  • 1229-1153(pISSN)
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  • 2465-9223(eISSN)
한국식품위생안전성학회 (The Korean Society of Food Hygiene and Safety)
권호 표지

옻나무 추출액(Rhus-II)의 안전성에 관한 유전독성학적 평가

Genotoxicicological Safety Estimate for the Rhus-II

  • 최창순 (오하이오 주립대학 수의과대학 병리학교실) ;
  • 한동운 (동물보호계열 천안연암대학)
  • Choi Changsun (Department of Pathology, College of Veterinary Medicine, Ohio State University) ;
  • Han Dong Un (Department of Animal Care, Cheonan Yonam College)
  • 발행 : 2005.03.01
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초록

These observations were performed to investigate the safety of the natural herbs (Rhus-II) in respect of genotoxicity. This substance was examined in two in-vitro tests: (1) Salmonella typhimurium reversion assay (Ames test) in strain TA 98, TA 100, TA 1535 and TA 1537, (2) in vitro chromosome aberration test in cultured Chinese hamster ovary (CHO) cells. In the reverse mutation test, Rhus-II did not induced mutagenicity in Salmonella typhimurium reversion assay(Ames test) with or without metabolic activation. In the chromosome aberration assay using CHO cells, there was no increased incidence of structural and numerical aberrations with or without metabolic activation. These results indicated that, the Rhus-II had no genotoxicity.

키워드

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