Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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The Study on the Serum Levels of Resistin, Adiponectin, and Leptin in Obese Children

비만 아동의 혈청 Resistin, Adiponectin 및 Leptin 농도에 관한 연구

  • Lee Hyun Sook (Department of Sports Science, Seoul Sports Graduate University) ;
  • Choi Jin Sun (Department of Food and Nutrition, Ewha Womans University) ;
  • Kim Wha Young (Department of Food and Nutrition, Ewha Womans University)
  • 이현숙 (서울스포츠대학원대학교 스포츠과학학과) ;
  • 최진선 (이화여자대학교 식품영양학과) ;
  • 김화영 (이화여자대학교 식품영양학과)
  • Published : 2005.04.01
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Abstract

Resistin, adiponectin, and leptin are hormones secreted by adipose tissue and are known to play an important role in adipose tissue metabolism. The purpose of this study was to evaluate the levels of adipocyte-derived hormones (resistin, adiponectin, leptin) in obese children aged 10-12 years. The subjects were 102 obese children with obesity index (OI) over $120\%$ and 51 control children with obesity index less than $120\%$ were included for comparison. Anthropometric variables and serological parameters were assessed. Height, weight, OI, body mass index (BMI) were significantly higher in obese group than in control. Obese children showed significantly higher serum concentrations of triglyceride (TG), total cholesterol (TC), and LDL-cho1esterol and significantly lower HDL-cholesterol compared with control children, even though the values were within normal ranges for both groups. Concentrations of resistin and leptin were significantly higher in obese group than in control. Adiponectin and insulin levels were tended to lower in obese group even though the differences were not statistically significant. Resistin had significant positive correlation with OI and TG, and 1eptin with weight, OI, BMI, TG and TC. On the other hand, adiponectin showed significant negative correlations with height, OI and BMI. These finding showed that obese children had higher serum levels of resistin and leptin and lower adiponectin, and also these hormones had correlations with related factors of obesity, suggesting adipocyte-derived hormones has a role in child obesity.

Keywords

References

  1. Kang YJ, Hong CH, Hong YJ. The prevalence of Childhood and Adolescent Obesity Over the Last 18 Years in Seoul Area. Kor J Nutr 30 (7): 832-839, 1997
  2. Busanmetropolitan City Office Education. Research on obese children, 2001
  3. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes. Nature 409(6818): 307-312, 2001 https://doi.org/10.1038/35053000
  4. Pi-Sunyer FX. Medical hazards of obesity. Ann Intern Med 119(2): 655-660, 1993 https://doi.org/10.7326/0003-4819-119-7_Part_2-199310011-00006
  5. Must A, Strauss RS. Risks and consequences of childhood and adolescent obesity. Int J Obes Relat Metab Disord 23 (Suppl 2) : S2-11, 1999
  6. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (5091): 87-91, 1993 https://doi.org/10.1126/science.7678183
  7. Steppan CM, Lazar MA. Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 13 (1): 18-23, 2002 https://doi.org/10.1016/S1043-2760(01)00522-7
  8. Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 276 (28): 25651-25653, 2001 https://doi.org/10.1074/jbc.C100189200
  9. Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, Vettor R. Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss. Obes Res 10(11): 1095-1103, 2002 https://doi.org/10.1038/oby.2002.149
  10. Fukui Y, Motojima K. Expression of resistin in the adipose tissue is modulated by various factors including peroxisome proliferator-activated receptor alpha. Diabetes Obes Metab 4 (5): 342-345, 2002 https://doi.org/10.1046/j.1463-1326.2002.00215.x
  11. Moore GB, Chapman H, Holder JC, Lister CA, Piercy V, Smith SA, Clapham JC. Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice. Biochem Biophys Res Commun 286(4): 735-741, 2001 https://doi.org/10.1006/bbrc.2001.5460
  12. Shojima N, Sakoda H, Ogihara T, Fujishiro M, Katagiri H, Anai M, Onishi Y, Ono H, Inukai K, Abe M, Fukushima Y, Kikuchi M, Oka Y, Asano T. Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells. Diabetes 51(6): 1737-1744, 2002 https://doi.org/10.2337/diabetes.51.6.1737
  13. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270 (45): 26746-26749, 1995 https://doi.org/10.1074/jbc.270.45.26746
  14. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86(5): 1930-1935, 2001 https://doi.org/10.1210/jc.86.5.1930
  15. Hotta K, Funahashi T, Bodkin NL, Ortrneyer HK, Arita Y, Hansen BC, Matsuzawa Y. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50(5): 1126-1133, 2001 https://doi.org/10.2337/diabetes.50.5.1126
  16. Chandran M, Phillips SA, CiaraIdi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes Care 26 (8) : 2442-2450, 2003 https://doi.org/10.2337/diacare.26.8.2442
  17. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7 (8): 947-953, 2001 https://doi.org/10.1038/90992
  18. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weightreducing effects of the plasma protein encoded by the obese gene. Science 269 (5223) : 543-546, 1995 https://doi.org/10.1126/science.7624777
  19. Pelleymounter MA, Cullec MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effect of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995 https://doi.org/10.1126/science.7624776
  20. Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Land B Biol Sci 140 (901) : 578-596, 1953
  21. Ahren B, Larsson H, Whihelmsson C. Regulation of circulating leptin levels in humans, Endocrinology 7: 1-7, 1997 https://doi.org/10.1210/endo-7-1-1
  22. Ravussin E, Pratley RE, Maffei M, Wang H, Friedman JM, Bennett PH, Bogardus C. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med 3 (2) : 238-240, 1997 https://doi.org/10.1038/nm0297-238
  23. Chessler SD, Fujimoto WY, Shofer JB, Boyko EJ, Weigle DS. Increased plasma leptin levels are associated with fat accumulation in Japanese Americans. Diabetes 47 (2): 239-243, 1998 https://doi.org/10.2337/diabetes.47.2.239
  24. Friedwald WT, Levy RI, Fredireck DS. Estimation of the concen-tration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chern 18: 499-502, 1972
  25. National cholesterol Education Program: Report of the expert panel on blood cholesterol levels in children and adolescents. Pediatrics 89 (Suppl.) : 523-576, 1992
  26. Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A, Saruta T. Correlation between serum resistin level and adiposity in obese individuals. Obes Res 11 (8): 997-1001, 2003 https://doi.org/10.1038/oby.2003.137
  27. Degawa- Yamauchi M, Bovenkerk JE, Iuliar BE, Watson W, Kerr K, Iones R, Zhu Q, Considine RY. Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab 88(11): 5452-5455, 2003 https://doi.org/10.1210/jc.2002-021808
  28. Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, Seip R, Orlova C, Mantzoros CS. Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab 88 (10): 4848-4856, 2003 https://doi.org/10.1210/jc.2003-030519
  29. Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E, Smith SR. Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J Clin Endocrinol Metab 89 (4): 1844-1848, 2004 https://doi.org/10.1210/jc.2003-031410
  30. Youn BS, Yu KY, Park HJ, Lee NS, Min SS, Youn MY, Cho YM, Park YJ, Kim SY, Lee HK, Park KS. Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. J Clin Endocrinol Metab 89 (1): 150-156, 2004 https://doi.org/10.1210/jc.2003-031121
  31. Chu NF, Chang JB, Shieh SM. Plasma leptin, fatty acids, and tumor necrosis factor-receptor and insulin resistance in children. Obes Res 11 (4): 532-540, 2003 https://doi.org/10.1038/oby.2003.75
  32. Valle M, Gascon F, Martos R, Bermudo F, Ceballos P, Suanes A. Relationship between high plasma leptin concentrations and metabolic syndrome in obese pre-pubertal children. Int J Obes Relat Metab Disord 27 (1): 13-18, 2003 https://doi.org/10.1038/sj.ijo.0802154
  33. Steinberger J, Steffen L, Jacobs DR Jr, Moran A, Hong CP, Sinaiko AR. Relation of leptin to insulin resistance syndrome in children. Obes Res 11 (9): 1124-1130, 2003 https://doi.org/10.1038/oby.2003.153
  34. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257 (1) : 79-83, 1999 https://doi.org/10.1006/bbrc.1999.0255
  35. Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, Ohashi K, Sakai N, Shimomura I, Kobayashi H, Terasaka N, Inaba T, Funahashi T, Matsuzawa Y. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 106 (22): 2767-2770, 2002 https://doi.org/10.1161/01.CIR.0000042707.50032.19
  36. Asayama K, Hayashibe H, Dobashi K, Uchida N, Nakane T, Kodera K, Shirahata A, Taniyama M .Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. Obes Res 11 (9): 1072-1079, 2003 https://doi.org/10.1038/oby.2003.147
  37. Ouehi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, Hotta K, Nishida M, Takahashi M, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y.Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Crculation 100(25): 2473-2476, 1999 https://doi.org/10.1161/01.CIR.100.25.2473
  38. Stefan N, Bunt JC, Salbe AD, Funahashi T, Matsuzawa Y, Tataranni PA. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 87 (10) : 4652-4656, 2002 https://doi.org/10.1210/jc.2002-020694