대한한방부인과학회지 (The Journal of Korean Obstetrics and Gynecology)

  • 제18권3호
  • /
  • Pages.1-16
  • /
  • 2005
  • /
  • 1229-4292(pISSN)
  • /
  • 2508-3619(eISSN)
대한한방부인과학회 (The Society of Korean Medicine Obstetrics and Gynecology)
권호 표지

귀신환(歸腎丸)이 백서(白鼠)의 배란(排卵)과 난소(卵巢)에 미치는 영향(影響)

Effects of Guisinhwan on the Ovulation and Ovary in Rats

  • 안규환 (원광대학교 한의과대학 부인과학교실) ;
  • 이승준 (원광대학교 한의과대학 부인과학교실) ;
  • 최창민 (원광대학교 한의과대학 부인과학교실) ;
  • 유심근 (원광대학교 한의과대학 부인과학교실)
  • Ahn, Kyu-Hwan (Department of Oriental Obstetric and Gynecology, College of Oriental Medicine, Wonkwang university) ;
  • Lee, Seung-Jun (Department of Oriental Obstetric and Gynecology, College of Oriental Medicine, Wonkwang university) ;
  • Choi, Chang-Min (Department of Oriental Obstetric and Gynecology, College of Oriental Medicine, Wonkwang university) ;
  • Yoo, Sim-Keun (Department of Oriental Obstetric and Gynecology, College of Oriental Medicine, Wonkwang university)
  • 발행 : 2005.08.31
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초록

Purpose : This study is to examine what are the effects of the Guisinhwan(GSH) on the ovulation and ovary in rats. Methods : 4weeks Female Sprague-Dawley 12 rats of weighting 160-l80g, were divided into three groups including the GSH oral administration(4ml/kg) groups(4heads) and GSH oral administration(8ml/kg)　groups(4heads). Then we observed changes in the serum concentrations of FSH, LH, and estradiol($E_2$) and the histological changes of ovary and the immunohistochemical staining for progesterone receptor in ovary of rats. Results : 1. GSH didn't make a difference as compared with control group in serum FSH level. 2. GSH didn't make a difference as compared with control group in serum LH level. 3. GSH significantly increased serum $E_2$ level. 4. GSH significantly increased ovulation in histological observations of ovary. 5. GSH tended to decrease immunohistochemical staining score (ISS) of atretic follicles in immunohistochemical staining for progesterone receptor in ovary. Conclusion : GSH influences ovary to increase the ovulation of rats.

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