Molecular & Cellular Toxicology

The Korean Society of Toxicogenomics and Toxicoproteomics (대한독성유전 단백체학회)
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Identification of Potential Carcinogenic Biomarker Following Exposure to N-ethyl-N-nitrosourea in Mice

  • Lim, Jung-Sun (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology) ;
  • Jeong, Sung-Young (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology) ;
  • Hwang, Ji-Yoon (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology) ;
  • Cho, Kyu-Hyuk (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology) ;
  • Cho, Jae-Woo (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology) ;
  • Han, Sang-Seop (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology) ;
  • Song, Chang-Woo (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology) ;
  • Yoon, Seok-Joo (Korea Institute of Toxicology, Korea Research Institute of Chemical Technology)
  • Published : 2005.06.30
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Abstract

N-ethyl-N-nitrosourea (ENU), which is a toxin and a carcinogen, as well as a mutagen, has a variety of effects on mice. ENU induces point mutation in male germ cell. Number of mutant animals are developed with ENU treatment. However, potentiality ot ENU as a carcinogen is not fully understood, even though, mutagenicity of ENU is broadly studied, In the present study, the gene expression profiling and histopathological investigation of ENU treated mouse's liver and brain were investigated. Also, the expression patterns of cancer related genes in ENU-treated mouse were analyzed.

Keywords

References

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