References
- Klaassen, C.D. Toxicology-the basic science and poisons (6th Ed.). (McGraw-Hill Co.) (2001)
- Newton, R.K., Aardema, M. & Aubrecht, J. The utility of DNA microarrays for characterizing genotoxicity. Environ. Health Perspect. 112, 420-422 (2004) https://doi.org/10.1289/ehp.6709
- McCann, J., Choi, E. Yamasaki E. & Ames, B.N. Detection of carcinogens as mutagens in the Salmonella/ microsome test: assay of 300 chemicals. Proc. Natl. Acad. Sci. USA 72, 5135-5139 (1975) https://doi.org/10.1073/pnas.72.12.5135
- Meselson, M. & Russell, K. Comparison of carcinogenic and mutagenic potency. In Origin of Human Cancer, Hiatt, H.H., Watson, J.D. & Winstend, J.A. eds. (Cold Spring Harbor Laboratory). 1473-1481 (1977)
- Zimmermann, F.K. Induction of mitotic gene conversion by mutagens. Mutat. Res. 11, 327-337 (1971)
- Radman, M., Jeggo, P. & Wagner, R. Chromosomal rearrangement and carcinogenesis. Mutat. Res. 98, 249-264 (1982). https://doi.org/10.1016/0165-1110(82)90035-5
- Ames, B.N., Durston, W.E., Yamasaki, E. & Lee, F.D. Carcinogens are mutagens : a simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci. USA 70, 2281-2285 (1973) https://doi.org/10.1073/pnas.70.8.2281
- Maron, D.M. & Ames, B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113, 173- 215 (1983) https://doi.org/10.1016/0165-1161(83)90010-9
- Mersch-Sundermann, V.S., Kerekordes, S. & Mochayedi, S. Sources of variability of the Escherichia coli PQ 37 genotoxicity assay (SOS chromotest). Mutat. Res. 252, 51-60 (1991) https://doi.org/10.1016/0165-1161(91)90251-3
- Ishidate, M. & Odashima, S. Chromosome test with 134 compounds on chinese hamster cells in vitro-A screening for chemical carcinogens. Mutat. Res. 48, 337-354 (1977) https://doi.org/10.1016/0027-5107(77)90177-4
- Hayashi, M., Morita, T., Kodama, Y., Sofuni, T. & Ishidate, M.Jr. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orangecoated slides. Mutat. Res. 245, 245-249 (1990) https://doi.org/10.1016/0165-7992(90)90153-B
- Hayashi, M. et al. in vivo rodent erythrocyte micronucleus assay. Mutat. Res. 312, 293-304 (1994) https://doi.org/10.1016/0165-1161(94)90039-6
- Ryu, J.C., Lee, S., Kim, K.R., Kim, M., Chang, I.M. & Park, J.A study on the clastogenicity of trichothecene mycotoxins in chinese hamster lung cells. Korean J. Toxicol. 9, 13-21 (1993a)
- Ryu, J.C., Kim, S.H., Kim, K.R., Lee, S., Kim, M., Jung, H. & Park, J.A study on the antimutagenic effect of cinnamic acid derivatives in Escherichia coli PQ 37 (SOS Chromotest) (I). Environ. Mutagens & Carcinogens 13, 8-17 (1993b)
- Ryu, J.C., Kim, H.J., Seo, Y.R. & Kim, K.R. Single Cell Gel Electrophoresis (Comet Assay) to detect DNA damage and Apoptosis in cell level. Environ. Mutagens & Carcinogens 17, 71-77 (1997)
- Ryu, J.-C., Kim, K.-R. & Choi, Y.-J. in vitro mouse lymphoma thymidine kinase (tk+/-) gene forward mutation assay in mammalian cells, Environ. Mut-agens & Carcinogens 19, 7-13 (1999b)
- Sato, T., Chikazawa, K., Yamamori, H., Ose, Y., Nagase, H. & Kito, H. Evaluation of the SOS chromotest for the detection of antimutagens. Environ. Mol. Mutagen. 17, 258-263 (1991) https://doi.org/10.1002/em.2850170407
- Ryu, J.C. & Park, K.Y. Anticlastogenic effect of Baechu (Chinese cabbage) Kimchi and Buchu(leek) Kimchi in supravital staining micronucleus assay using peripheral reticulocytes of mouse. Environ. Mutagens & Carcinogens 21, 51-56 (2001b)
- Schmid, W. The micronucleus test. Mutat. Res. 31, 9-15 (1975) https://doi.org/10.1016/0165-1161(75)90058-8
- Ryu, J.C., Choi, Y.J., Kim, Y.J., Kim, H.T. & Bang, H.A. Recent advanced toxicological methods for environmental hazardous chemicals. Kor. J. Environ. Toxicol. 14, 1-12 (1999c) https://doi.org/10.1002/(SICI)1522-7278(199902)14:1<1::AID-TOX1>3.0.CO;2-I
- Ryu, J.C. Current Trend of Advanced Methods in Cellular and Molecular Toxicology. Environ. Mutagens & Carcinogens 22, 1-11 (2002a)
- Ryu, J.C. Introduction of Recent Advanced Cellular and Molecular Toxicology. Kor. J. Pesticide Sci. 6, 157-165 (2002b)
- Mckelvey-Martin, V.J., Green, M.H.L., Schemezer, P., Pool-Zobel, B.L., De Meo, M. & Collins, A. The single cell gel electrophoresis assay (comet assay): A european review. Mutat. Res. 288, 47-63 (1993) https://doi.org/10.1016/0027-5107(93)90207-V
- Singh, N.P., McCoy, M.T., Tice, R.R. & Schneider, E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184-191 (1988) https://doi.org/10.1016/0014-4827(88)90265-0
- Singh, N.P., Tice, R.R. & Stephens, R.E. A microgel electrophoresis technique for the direct quantitation of DNA and repair in individual fibroblasts cultured on microscope slides. Mutat. Res. 252, 289-296 (1991) https://doi.org/10.1016/0165-1161(91)90008-V
- Singh, N.P., Stephens, R.E. & Schneider, E.L. Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int. J. Radiat. Biol. 66, 23-28 (1994) https://doi.org/10.1080/09553009414550911
- Tice, R.R. et al. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 35, 206-221 (2000) https://doi.org/10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J
- Clive, D., McCuen, R., Spector, J.F. S., Piper, C. & Mavournin, K. H. Specific gene mutations in L5178Y cells in culture: A report of the U.S. Environmental Protection Agency Gen-Tox Program. Mutat. Res. 115, 225-251 (1983) https://doi.org/10.1016/0165-1110(83)90005-2
- Abbo, S., Dunford, R.P., Miller, T.E., Reader S.M. & King I. P. Primer-mediated in situ detection of the Bhordein gene cluster on barley chromosomes 1H. Genetics 90, 11821-11824 (1993)
- Kohler, S.W., Provost, G.S., Fieck, A., Kretz, P.L., Bullock, W.O., Sorge, J.A., Putman, D.L. & Short, J. M. Spectra of spontaneous and mutagen-induced mutations in the lac I gene in transgenic mice. Proc. Natl. Acad. Sci. USA 88, 7958-7962 (1991) https://doi.org/10.1073/pnas.88.18.7958
- Ryu, J.C., Youn, J.Y., Cho, K.H. & Chang, I.M. Mutation spectrum in lacI gene of transgenic Big Blue cell line following to short term exposure 4-nitroquinoline- N-oxide. Environ. Mol. Mutagen. 31, 16 (1998a)
- Ryu, J.C., Youn, J.Y., Cho, K.H. & Chang, I.M. Transgenic Mutagenesis assay to elucidate the mechanism of mutation in gene level. Environ. Mutagens & Carcinogens 18, 1-7 (1998b)
- Ryu, J.C., Youn, J.Y., Kim, Y.J., Kwon, O.S., Kim, H.T., Cho, K.H. & Chang, I.M. Mutation spectrum of 4-nitroquinoline-N-oxide in the lacI transgenic Big Blue Rat2 cell line. Mutat. Res. 445, 127-135 (1999a) https://doi.org/10.1016/S1383-5718(99)00136-9
- Ryu, J.C., Kim, Y.J., Kim, H.T. & Chai, Y.G. Genotoxicity Assessment of atrazine in the Big Blue rat2 lacI transgenic cell line. Environ. Mol. Mutagen. 35, 52 (2000)
- Ryu, J.C. & Kim, Y.J. Mutation spectrum of 1,2- dibromo-3-chloropropane, an endocrine disruptor, in the lac I transgenic Big Blue rat2 fibroblast cell line. Environ. Mol. Mutagen. 37, 65 (2001c)
- Suzuki, T., Hayashi, M., Sofuni. T. & Myhr, B.C. The concomitant detection of gene mutation and micronucleus induction by mitomycin C in vivo using lac Z transgenic mice. Mutat. Res. 285, 219-224 (1993) https://doi.org/10.1016/0027-5107(93)90109-S
- Aederma, M.J. & MacGregor, J.T. Toxicology and genetic toxicology in the new era of 'toxicogenomics': impact of '-omics' technologies. Mutat. Res. 499, 13-25 (2002) https://doi.org/10.1016/S0027-5107(01)00292-5
- Hamadeh, H.K. & Afsari, C.A. Toxicogenomics-principles and applications (Jon Wiley and Sons, Inc.) (2004)
- Ostling, O. & Johanson, K.J. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem. Biophy. Res. Commun. 123, 291-298 (1984) https://doi.org/10.1016/0006-291X(84)90411-X
-
Singh, N.P., Graham, M.M., Singh, V. & Khan, A. Induction of DNA single-strand breaks in human lymphocytes by low doses of
${\gamma}-rays$ . Int. J. Radiat. Biol. 68, 563-569 (1995) https://doi.org/10.1080/09553009514551551 - Olive, P.L., Garnet, F. & Judit, P.B. Radiation-induced apoptosis measured in tk6 Human B lymphocytes cells using the comet assay. Radiat. Res. 136, 130- 136 (1993) https://doi.org/10.2307/3578650
- Olive, P.L., Banath, J.P. & Fjell, C.D. DNA strand breakage and DNA structure influence staining with propidium iodide using the alkaline comet assay. Cytometry 16, 305-312 (1994) https://doi.org/10.1002/cyto.990160404
- Ryu, J.C., Seo, Y.R., Smith, M.A. & Han, S.S. The Effect of methyl methanesulfonate (MMS)-induced excision repair on p53-dependent apoptosis in human lymphoid cells. Res. Commun. Mol. Pathol. Pharmacol. 109, 35-51 (2001a)
- Ryu, J.C., Kim, H.T. & Kim, Y.J. Studies on DNA single strand break of seven phthalate analogues in mouse lymphoma cells. Environ. Mutagens & Carcinogens 22, 164-168 (2002c)
- Fairbairn, D.W., Olive, P.L. & O'Neill, K.L. The comet assay: a comprehensive review. Mutat. Res. 339, 37-59 (1995) https://doi.org/10.1016/0165-1110(94)00013-3
- Fairbairn, D.W., Walburger, D.K., Fairbairn, J.J. & O'Neill, K.L. Key morphologic changes and DNA strand breaks in human lymphoid cells: discriminating apoptosis from necrosis. Scanning 18, 407-416 (1996) https://doi.org/10.1002/sca.1996.4950180603
- Clive, D., Flamm, W.G., Machesko, M.R. & Bernheim, N.J. A mutational assay system using the thymidine kinase locus in mouse lymphoma cells. Mutat. Res. 16, 77-87 (1972) https://doi.org/10.1016/0027-5107(72)90066-8
- Clive, D. & Spector, J.F. S. Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells. Mutat. Res. 31, 17-29 (1975) https://doi.org/10.1016/0165-1161(75)90059-X
-
Cole, J., Muriel, W.J. & Bridges, B.A. The mutagenicity of sodium fluoride to L5178Y [wild-type and
$TK_{1/2}$ (3.7.2C)] mouse lymphoma cells. Mutagenesis 1, 157-167 (1986). https://doi.org/10.1093/mutage/1.2.157 - Applegate, M.L., Moore, M.M., Broder, C.B., Blurrell, A., Juhn, G., Kaswek, K.L., Lin, P.-F., Wadhams, A. & Hozier, J.C. Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells. Proc. Natl. Acad. Sci. U S A 87, 51-55 (1990) https://doi.org/10.1073/pnas.87.1.51
- Moore, M.M., Clive, D., Hozier, J.C., Howard, B.E., Batson, A.G., Turner, N.T. & Sawyer, J. Analysis of trifluorothymidine-resistant (TFTr) mutants of L51- 78Y TKC- mouse lymphoma cells. Mutat. Res. 151, 161-174 (1985) https://doi.org/10.1016/0027-5107(85)90194-0
- Hozier, J., Sawyer, J., Moore, M., Howard, B. & Clive, D. Cytogenetic analysis of the L5178Y/TKC-/- mouse lymphoma mutagenesis assay system. Mutat. Res. 84, 169-181 (1981) https://doi.org/10.1016/0027-5107(81)90060-9
- Blazak, W.F., Los, F.J., Rudd, C.J. & Caspary, W.J. Chromosome analysis of small and large L5178Y mouse lymphoma cell colonies. Comparison of trifluorothymidine- resistant and unselected cell colonies from mutagen-treated and control cultures. Mutat. Res. 224, 197-208 (1989) https://doi.org/10.1016/0165-1218(89)90156-0
- Liechty, M.C., Scalzi, J.M., Sims, K.R., Crosby Jr., H., Spencer, D.L., Davis, L.M., Caspary, W.J. & Hozier, J.C. Analysis of large and small colony L5178Y tk-/- mouse lymphoma mutants by loss of heterozygosity (LOH) and by whole chromosome 11 painting: detection or recombination. Mutagenesis 13, 461-474 (1998) https://doi.org/10.1093/mutage/13.5.461
- Brenneke, H.P.U.H. Die Ursache des herabgesetzten Wurfgrobe bei Mausen nach Rontgenbestrahlung des Samens, Z.A.V. (1937)
- Thoday, J.M. The effect of ionizing radiation on the broad bean root. Part IX. Chromosome breakage and the lethality of ionizing radiations to the root meristem. Br. J. Radiol. 24, 276-572 (1951)
- Evans, H.J., Neary, G.J. & Williamson, F.S. The relative biological efficiency of single doses of fast neutrons and gamma rays in Vicia faba roots and the effect of oxygen. Part II. Chromosome damage; the production of micronuclei. Intl. J. Rad. Biol. 1, 230-240 (1959) https://doi.org/10.1080/09553005914550321
- Boller, K. & Schmid, W. Chemical mutagenesis in mammals. The Chinese hamster bone marrow as an in vivo test system. Hematological findings after treatment with trenimon. Humangenetik 11, 35-54 (1970) https://doi.org/10.1007/BF00296302
- Heddle, J.A. A rapid in vivo test for chromosome damage. Mutat. Res. 18, 187-190 (1973) https://doi.org/10.1016/0027-5107(73)90035-3
- Countryman, P.I. & Heddle, J.A. The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat. Res. 41, 321-332 (1976) https://doi.org/10.1016/0027-5107(76)90105-6
- MacGregor, J.T., Wehr, C.M. & Gould, D.H. Clastogen- induced micronuclei in peripheral blood erythrocytes: The basis of an improved micronucleus test. Environ. Mutagen. 2, 509-514 (1980) https://doi.org/10.1002/em.2860020408
- Heddle, J.A., Hite, M., Kirkhart, B., Mavournin, K., MacGregor, J.T., Newell, G.W. & Salamone, M.F. The induction of micronuclei as a measure of genotoxicity. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res. 123, 61- 118 (1983) https://doi.org/10.1016/0165-1110(83)90047-7
- Fenech, M. & Morley, A.A. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutat. Res. 161, 193-198 (1986) https://doi.org/10.1016/0027-5107(86)90010-2
- Fenech, M., Crott, J., Turner, J. & Brown, S. Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide. Mutagenesis 14, 605-612 (1999) https://doi.org/10.1093/mutage/14.6.605
- Gorelick, N.J. Overview of mutation assays in transgenic mice for routine testing. Environ. Mol. Mutagen. 25, 218-230 (1995) https://doi.org/10.1002/em.2850250309
- Dycaico, M.J., Provost, G.S., Kretz, P.L., Ransom, S. L., Moores, J.C. & Short, J.M. The use of shuttle vectors for mutation analysis in transgenic mice and rats. Mutat. Res. 307, 461-478 (1994) https://doi.org/10.1016/0027-5107(94)90257-7
- Heddle, J.A. & Tao, K.S. The transmission rate of the lacI transgene from the Big Blue mouse. Mutat. Res. 348, 63-66 (1995) https://doi.org/10.1016/0165-7992(95)00047-X
- Summers, W.C., Glazer, P.M. & Malkevich, D. Lambda phage shuttle vector for analysis of mutations in mammalian cells in cultures and in transgenic mice. Mutat. Res. 220, 263-268 (1989) https://doi.org/10.1016/0165-1110(89)90030-4
- Gossen, J.A., De Leeuw, W.J., Tan, C. H., Zworthoff, E.C., Berends, F., Lohman, P.H., Knook, D.L. & Vijg, J. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. USA 86, 7971-7975 (1989) https://doi.org/10.1073/pnas.86.20.7971