Plant Resources
- 제8권3호
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- Pages.209-216
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- 2005
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- 1226-8771(pISSN)
Anti Angiogenic Effects of Isorhamnetin Isolated from Persicaria thunbergii
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Lee Hyo-Jung
(Department of Oncology, Graduate School of East-West Medical Science, Kyung Hee University) ;
- Kim Kwan-Hyun (Department of Oncology, Graduate School of East-West Medical Science, Kyung Hee University) ;
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Baek Nam-In
(Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
- Kim Dae-Keun (Department of Pharmacy, WooSuk University) ;
- Yang Deok-Chun (Department of Oriental Medicinal Materials and Processing, Kyung Hee University) ;
- Kim Sung-Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyung Hee University)
- 발행 : 2005.12.01
초록
Persicaria thunbergii has been utilized for the treatment of cancer as a folk medicine. We examined the effect of isorhamnetin, a flavonoid isolated from Persicaria thunbergii, on angiogenesis in vitro and in vivo. Basic fibroblast growth factor (bFGF) is a potent angiogenic factor found in various tumors. In this study, we found that the isorhamnetin decreased bFGF-induced human umbilical vein endothelial cells (HUVECs) proliferation and migration in a concentration-dependent manner (5, 10 and