Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)
- Volume 19 Issue 5
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- Pages.1405-1410
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- 2005
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- 1738-7698(pISSN)
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- 2288-2529(eISSN)
Inhibition of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 by Gamijihwang-tang Via Suppression of Nuclear Factor-B Activation in RAW 264.7 cells
- Jang Du-Hyun (Department of Gynecology, College of Oriental Medicine, Daejeon University) ;
- Kim Ji-Young (Department of Pharmacy, College of Pharmacy, Chosun University) ;
- Han Eun-Hee (Department of Pharmacy, College of Pharmacy, Chosun University) ;
- Park Hee-Ok (Department of Food and Drug, Chosun University) ;
- Kim Dong-Hee (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
- Jeong Hye-Gwang (Department of Pharmacy, College of Pharmacy, Chosun University) ;
- Yoo Dong-Yeol (Department of Gynecology, College of Oriental Medicine, Daejeon University)
- Published : 2005.10.01
Abstract
Asthma is recognized today as an inflammatory disease of the lung characterized by acute non-specific airway hypersensitiveness in association with chronic pulmonary inflammation. Gamijihwang-tang(GJT), a fortified prescription of YMJHT, is applied for the treatments of chronic coughing and asthma, and post-delivery coughing and asthma in the gynecology. Also in the clinical practice, GJT is known to be very effective for controlling coughing and asthma as a cold sequoia. In this study, we investigated the effects of GJT on the lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin