Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Immunity Effect of the Sogyughwalhyel-tanggami in Collagen-induced Arthritis Mice

Type II Collagen으로 유발된 관절염에 대한 소경활혈탕가미의 면역 억제 효과

  • Lee Joong-Whee (Department of Oriental Medicine, College of Oriental Medicine, Daejeon University) ;
  • Oh Min-Suck (Department of Oriental Medicine, College of Oriental Medicine, Daejeon University)
  • 이중휘 (대전대학교 한의과대학 한방재활의학교실) ;
  • 오민석 (대전대학교 한의과대학 한방재활의학교실)
  • Published : 2005.10.01
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Abstract

This study was carried out to know the immunity responses of Sogyughwalhyel-tanggami(SGHHT) to on Rheumatoid Arthritis in Collagen-induced Arthritis(CIA) Mice. Various experimental were peformed to analyse the immunity effects of SGHHT. The cytotoxicity against mLFCs was not measured. The production of pro-inflammatory cytokines $IL-1{\beta}$, IL-6, $TNF-\alpha$ were reduced in hFLSs. The production of pro-inflammatory cytokines $IFN-\gamma$, IgG3, IgG2b, IgM were reduced. Comparison of the results for this study showed that SGHHT had immunomodulatory effects of suppressing or enhancing. So we expect that SGHHT should be used as a effective drugs for not only rheumatoid arthritis but also another auto-immune disease. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.

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