Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)
- Volume 19 Issue 5
- /
- Pages.1267-1271
- /
- 2005
- /
- 1738-7698(pISSN)
- /
- 2288-2529(eISSN)
Study on Effect of GyeongshinhaeGihwan 1 in Body Weight and Food Intake for High fat Diet Induced Obese Male Rats
고지방식이 수컷 비만백서에서 경신해지환(輕身解脂丸)이 체중 및 사료섭취량에 미치는 영향
-
Jung Yang-Sam
(Department of Prescriptionology, College of Oriental Medicine, Dongeui University) ;
-
Yoon Ki-Hyeon
(Department of Prescriptionology, College of Oriental Medicine, Dongeui University) ;
- Choi Seung-Bae (Department of Computer Science and Statistics, Dongeui University) ;
-
Shin Soon-Shik
(Department of Prescriptionology, College of Oriental Medicine, Dongeui University)
-
정양삼
(동의대학교 한의과대학 방제학교실) ;
-
윤기현
(동의대학교 한의과대학 방제학교실) ;
- 최승배 (동의대학교 자연과학대학 정보통계학) ;
-
신순식
(동의대학교 한의과대학 방제학교실)
- Published : 2005.10.01
Abstract
To investigate the effect of the frequently used anti-obese medicine GyeongshinhaeGihwan 1 (GGT1), in food intake, body weight and food efficiency ratio for high fat diet induced obese male rats. Also, to value the diffences between GyeogshinhaeGihwan 1 and FDA approved Sibutramine in anti-obesity effect. High fat diet induced obese male rats were classified into four groups - positive control group, negative control group, GyeongshinhaeGihwan 1 group and Sibutramine group - and their food intake and body weight were observed for eight weeks. Anti-obesity effect was estimated with food efficiency ratio which is calculated by weight inclose divided by food intake. The result shown in Fig. 2 suggests that the GyeongshinhaeGihwan 1 group is more effective on food intake control than the Sibutramine group. Average weight variation shows an increase in both positive/negative control group and medication group. Also, the result in Fig. 3 indicates that average food efficiency ratio decreases contrary to the average weight variation. In addition, repeatedly estimated variance analysis on average food efficiency ratio of the GyeonushinhaeGihwan 1 group shows (1) the result corollary to the time of observation of food efficiency ratio was effective under 0.05 variance (P-value 0.000). The differences between each groups were not shown under 0.05 variance. Compared to the control group, medication groups were visually more effective on food intake control. Although both groups had a tendency of weight increasing, food efficiency ratio considering food intake and weight variation rate showed a decrease. Especially, the medication group variated less than the control group corollary to the point of time, proving the individuals react less sensitive to the medicine. Moreover, there were no differences in the anti-obesity effect between GyeongshinhaeGihwan 1 group and Sibutramine group studied by repeatedly estimating variance analysis(P-value: 0.610). When considering Sibutramine as an anti-obesity medicine approved by FDA, the point of being classifed in the same group proves the effect of GyeongshinhaeGihwan 1 as an anti-obesity medicine.
Keywords