동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제19권6호
  • /
  • Pages.1534-1540
  • /
  • 2005
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

대황목단탕(大黃牧丹湯)의 요산지표 개선효과와 관련 유전자 탐색

Effects of Daihwangmudan-tang on Urate Lowering and Detection of Relevant Genes

  • 김중배 (동의대학교 한의과대학 병리학교실) ;
  • 지규용 (동의대학교 한의과대학 병리학교실) ;
  • 엄현섭 (동의대학교 한의과대학 병리학교실)
  • Kim Joong-Bae (Department of Oriental Pathology, College of Oriental Medicine, Dongeui University) ;
  • Chi Gyoo-Yong (Department of Oriental Pathology, College of Oriental Medicine, Dongeui University) ;
  • Eom Hyun-Sup (Department of Oriental Pathology, College of Oriental Medicine, Dongeui University)
  • 발행 : 2005.12.01
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초록

In order to testify the urate lowering effects of Daihwangmudan-tang(DMT), ICR mice were injected monosodium urate into the abdominal cavity and then DMT was administered on 2 and 4 days after Injection. Uric acid and triglyceride were measured as hematological indices of gout, and some genes related with this change were identified by ACP based GeneFishing PCR method and direct sequencing. From this experiment, DMT highly decreased the blood levels of uric acid and significantly suppressed and lowered the acute increment of triglyceride level. There were 11 differentially expressed genes(DEG) having relations with positive actions of DMT, and 4 major genes in the middle of DEGs were sequenced; Mfap 2, jagged 2, Hsd17b7, DkkI-1, These genes were supposed that several mechanisms through interleukin 1 and T-cell anergy, LDL cholesterol metabolism, wnt pathway would be related with the anti-inflammation effect against gout.

키워드

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