Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The effect of Scolopendrid Aqua-acupuncture applied to the L14 on Galactosamine-induced liver injury

기문(期門)에 대한 오공약침(蜈蚣藥鍼)이 D-Galactosamine으로 유발(誘發)된 간손상(肝損傷)에 미치는 영향(影響)

  • Choi, Hoi-kang (Dept. of Acupunction and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Kim, Sung-chul (Dept. of Acupunction and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Yun, Dae-hwan (Dept. of Meridian and Acupoint, College of Oriental Medicine, Dong-Shin University) ;
  • Na, Chang-su (Dept. of Meridian and Acupoint, College of Oriental Medicine, Dong-Shin University) ;
  • Kim, Sung-nam (Dept. of Acupunction and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Lim, Jeong-a (Dept. of Acupunction and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Lee, Sung-yong (Dept. of Acupunction and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • So, Ki-suk (Dept. of Acupunction and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Cho, Nam-geun (Dept. of Acupunction and Moxibustion, Oriental Medical Hospital, Won-Kwang University) ;
  • Hwang, Woo-joon (Dept. of Acupunction and Moxibustion, Oriental Medical Hospital, Won-Kwang University)
  • Received : 2005.01.14
  • Accepted : 2005.05.14
  • Published : 2005.06.20
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Abstract

Objective : The purpose of this study is to observe the effects of Scolopendrid Aqua-acupuncture applied to the L14 on galactosamine-induced liver injury in rats. Methods : In this study, the experimental rats were divided four groups(Control group, SHA-1, SHA-2, SHA-3 group). In the Control group, we first injected galactosamine and then didn`t treated. In the SHA-1, SHA-2, SHA~3 group, we first Injected galactosamine and then injected Scolopendrid aqua-acupuncture applied to L14, each 0.083mg/kg, 0.017 mg/kg, 0.008mg/kg. We observed the changes of GOT, GPT, ${\gamma}$-GTP, Total bilirubin, LDH, ALP, Total cholesterol, Triglyceride, HDL-cholesterol, WBC, RBC, HGB, Hct. Results & Conclusion: 1. In the change of GPT content, as compared with control group, SHA-2, SHA-3 groups were significantly decreased. 2. In the change of ${\gamma}$-GTP content, as compared with control group, SHA-1, SHA-2 groups were significantly decreased. 3. In the change of Total bilirubin content, as compared with control group, SHA-2 group was significantly decreased.

기문혈(期門穴)에 대한(對) 오공자약침(蜈蚣雌藥鍼)이 D-Galactosamine에 의하여 유발된 간손상(肝損傷)에 미치는 영향을 실험적으로 규명하고자 흰쥐에게 약침을 처치한 후 혈청내의 G0T GPT, ${\gamma}$-GTP, Total bilirubin, LDH, ALP, Total cholesterol, Triglyceride 및 혈 액액내의 WBC, RBC, HGB, Hct 등을 관찰한 바 다음과 같은 결과를 얻었다. 1. GPT변화에서 대조군에 비하여 SHA-2군과 SHA-3군이 유의한 감소를 보였다. 2. Total bilirubin변화에서 대조군에 비하여 SHA-1군, SHA-2군과 SHA-3군이 유의한 감소를 보였다. 3. ${\gamma}$-GTP변화에서 대조군에 비하여 SHA-1군 과 SHA-2군이 유의한 감소를 보였다. 4. Total cholesterol변화에서 대조군에 비하여 SHA-2 군이 유의한 증가를 보였다. 5. Triglyceride변화에서 대조군에 비하여 SHA-1군, SHA-2군과 SHA-3군이 유의한 감소를 보였다. 6. HDL-cholesterol변화에서 대조군에 비하여 SHA-2군이 유의한 증가를 보였다. 7. 혈액내 변화에서 대조군에 비하여 WBC는 SHA-2군에서 유의한 감소를 보였으며, RBC는 SHA-2군과 SHA-3군에서 유의한 증가를 보였고, HGB는 SHA-2군과 SHA-3군에서 유의한 증가를 보였으며, Hct는 SHA-3군에서 유의한 증가를 보였다. 이상의 실험결과를 종합해보면 오공약침이 D-galactosamine으로 유발된 백서의 간손상에 효과적이라고 생각되며 간손상에 대한 예방, 치료적인 부분에서 향후 지속적인 연구가 필요하리라고 사료된다.

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