Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Genotoxicity Studies of Chrysin

Chrysin의 유전독성에 관한 연구

  • Jee Seungwan (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim Changhwan (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park Misun (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Eom Miok (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Ryeom Taikyung (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim Okhee (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kang Hoil (National Institute of Toxicological Research, Korea Food and Drug Administration)
  • 지승완 (식품의약품안전청 국립독성연구원) ;
  • 김창환 (식품의약품안전청 국립독성연구원) ;
  • 박미선 (식품의약품안전청 국립독성연구원) ;
  • 엄미옥 (식품의약품안전청 국립독성연구원) ;
  • 염태경 (식품의약품안전청 국립독성연구원) ;
  • 김옥희 (식품의약품안전청 국립독성연구원) ;
  • 강호일 (식품의약품안전청 국립독성연구원)
  • Published : 2005.03.01
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Abstract

Chrysin (5,7-dihydroxyflavone) is a flavonoid compound contained in many fruits, vegetables and honey. In our experiment, we investigated genotoxicity of chrysin using bacterial reverse mutation assay, chromosomal aberration test, in vivo micronucleus test. In bacterial reverse mutation assay, chrysin did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA102 with and without metabolic activation. In chromosome aberration test, chrysin did not also induce structural and numerical abberations regardless of metabolic activation in Chinese hamster lung fibroblast cells. In mouse micronucleus test, no significant increase in the occurrence of micronucleated polychromatic erythrocytes (MNPCE) was observed in ICR male mice orally administered with chrysin at the dose of 0.5, 1.0, 2.0 g/kg body weight. Taken together these results, chrysin has no mutagenic potential in our experiment.

Keywords

References

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