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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis, Analgesic, and Anti-Inflammatory Activities of [6-(3,5-Dimethyl-4-Chloropyrazole-1-yl)-3(2H)-Pyridazinon-2-yl]Acetamides

  • Sukuroglu, Murat (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University) ;
  • Caliskanergun, Burcu (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University) ;
  • Unlu, Serdar (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University) ;
  • Sahin, M.Fethi (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University) ;
  • Kupeli, Esra (Department of Pharmacognosy, Faculty of Pharmacy, Gazi University) ;
  • Yesilada, Erdem (Department of Pharmacognosy, Faculty of Pharmacy, Gazi University) ;
  • Banoglu, Erden (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University)
  • Published : 2005.01.01
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Abstract

A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4- chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analygesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.

Keywords

References

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