Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Single Oral Dose Toxicity Studies of Polycan, β-Glucan Originated from Aureobasidium in Mice

  • Lee, Hyeung-Sik (Department of Herbal Biotechnology, Daegu Haany University) ;
  • Yang, Kun-Ju (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Shin, Hyun-Dong (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Park, Bok-Ryeon (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Son, Chang-Woo (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Jang, Hee-Jeong (Glucan Corp. Research Institute, Marine Biotechnology Center) ;
  • Park, Dong-Chan (ENZ BIO Co., Kyungpook National University) ;
  • Jung, Young-Mi (ENZ BIO Co., Kyungpook National University) ;
  • Ku, Sae-Kwang (Pharmacology & Toxicology Lab., Central Research Laboratories, Dong Wha Pharm. Ind. Co.)
  • Published : 2005.12.01
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Abstract

This study was conducted to obtain the acute information of the oral dose toxicity of Polycan - originated from Aureobasidium pullulans SM-2001 (half of the dry material is -1,3/1,6-glucans), a UV induced mutant of A. pullulans, having various pharmacological effects, in male and female mice. In order to calculate $50\%$ lethal dose $(LD_{50})$, approximate LD and target organs, test article was administered twice by oral gavage to male and female ICR mice at total 1000, 500 and 250mg/kg. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing. As the results, we could not find any mortalities, clinical signs, changes in the body weight and gross findings. The results obtained in this study suggest that the Polycan is non-toxic in mice and is therefore likely to be safe for clinical use. The L050 and approximate $(LD_{50})$ in mice after single oral dose of Polycan were considered over 1000 mg/kg, respectively.

Keywords

References

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