The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Effects of Leucocyanidins on TCDD-Induced Lipid Peroxidation in Female Rat

흰쥐에서의 2,3,7,8-Tetrachlorodibenzo-p-Dioxine 유발 지질 과산화 반응에 대한 Leucocyanidins(Vitis vinifera L.)의 효과

  • Jhee Ok-Hwa (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University, Dept. of Pathology, College of Medicine, Hanyang University) ;
  • Lee Joo-Won (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University) ;
  • Kim Shin-Hee (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University) ;
  • Won Hei-Dan (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University) ;
  • Kim Hyun-Jin (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University) ;
  • Park Yun-Young (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University) ;
  • Kang Min-Jeong (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University, Dept. of Pathology, College of Medicine, Hanyang University) ;
  • Park Sung-Kug (Food Additives Team, Korea Food and Drug Administration) ;
  • Om Ae-Sun (Dept. of Pathology, College of Medicine, Hanyang University) ;
  • Back Seung-Sam (Dept. of Food & Nutrition, College of Human Ecology & Institute of Biomedical Science, Hanyang University) ;
  • Kang Ju-Seop (Dept. of Pharmacology & Clinical Pharmacology Lab, Institute of Biomedical Sciences, College of Medicine, Hanyang University)
  • 지옥화 (한양대학교 의과대학 약리학교실 임상약리학 실험실, 한양대학교 생물과학대학 식품영양학과) ;
  • 이주원 (한양대학교 의과대학 약리학교실 임상약리학 실험실) ;
  • 김신희 (한양대학교 의과대학 약리학교실 임상약리학 실험실) ;
  • 원해단 (한양대학교 의과대학 약리학교실 임상약리학 실험실) ;
  • 김현진 (한양대학교 의과대학 약리학교실 임상약리학 실험실) ;
  • 박윤영 (한양대학교 의과대학 약리학교실 임상약리학 실험실) ;
  • 강민정 (한양대학교 의과대학 약리학교실 임상약리학 실험실, 한양대학교 생물과학대학 식품영양학과) ;
  • 박성국 (식품의약품안전청 식품첨가물팀) ;
  • 엄애선 (한양대학교 생물과학대학 식품영양학과) ;
  • 백승남 (한양대학교 의과대학 병리학교실) ;
  • 강주섭 (한양대학교 의과대학 약리학교실 임상약리학 실험실)
  • Published : 2005.12.01
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Abstract

Effects of leucocyanidins on the level of serum lipids and lipid peroxidation was investigated in 2,3,7,8-tetrachlorodibenzo-p-dioxine(TCDD)-induced rat that were pretreated with leucocyanidins for 4 weeks. The rats were divided into five experimental groups that is leucocyanidins and low TCDD treated group(LTL, 0.1 ${\mu}\;g/kg$ TCDD), leucocyanidins treated high TCDD group(LTH, 10 ${\mu}\;g/kg$ TCDD), No leucocyanidins and low TCDD treated group(NTL, 0.1 ${\mu}\;g/kg$ TCDD) and no leucocyanidins and high TCDD treated group(NTL, 10 ${\mu}\;g/kg$ TCDD). Serum total cholesterol, LDL-cholesterol and triglyceride level were significantly decreased and HDL-cholesterol level significantly increased in leucocyanidins treated group. Serum MDA level was also significantly reduced in leucocyanidins treated group. These results suggest that pre-supplement of leucocyanidins prevented the degree of lipid peroxidation on TCDD induced rat.

Keywords

References

  1. Hinsdill, RD, Couch, DL and Speirs, RS. Immunosuppression in mice induced by dioxin (TCDD) in feed. J. Environ. Pathol. Toxicol. 4:401-25. 1980
  2. Huff, J. 2,3,7,8-TCDD: A potent & complete carcinogen in experimental animals. Chemosphere 25: 173-176. 1992 https://doi.org/10.1016/0045-6535(92)90506-M
  3. Dibartolomeis, MJ, Moore, RW, Peterson, RE and Jefcoate, CR. Hypercholesterolemia and the regulation of adrenal steroidogenesis in 2,3,7,8-tetrachlorodibenzo-${\rho}$-dioxine treated rats. Tox. Appl. Pharm. 85:313-323. 1986 https://doi.org/10.1016/0041-008X(86)90338-8
  4. Chapman, DE and Schiller, CM. Dose-Related effects of 2,3,7,8-tetracWorodibenzo-${\rho}$-dioxin(TCDD) in C57 BL/6J and DBA/2J mice. Tax. Appl. Pharm. 78:147-157. 1985 https://doi.org/10.1016/0041-008X(85)90314-X
  5. Calabrese, G. Table grape nutritional value. Bulletin de l'OIV, 76:863-864, 122-134. 2003
  6. Frankel, E, Kanner, J, German, J, Parks, E and Kinsella, J. Inhibition of oxidation of human low-density lipoprotein with phenolic substances in red wine. Lancet 341:454-457. 1993 https://doi.org/10.1016/0140-6736(93)90206-V
  7. Teissedre, P, Frankel, E, Waterhouse, A, Peleg, H and German, J. Inhibition of in vitro human LDL oxidation by phenolic antioxidants from grapes and wines. J. Sci. Food Agri. 70:55-61. 1996 https://doi.org/10.1002/(SICI)1097-0010(199601)70:1<55::AID-JSFA471>3.0.CO;2-X
  8. Muthaiya Balu, M, Sangeetha, P, Murali, G and Panneerselvam, e. Age-related oxidative protein damages in central nervous system of rats: modulatory role of grape seed extract. Int. J. Develop. Neuroscience 23: 501-507. 2005 https://doi.org/10.1016/j.ijdevneu.2005.06.001
  9. Vivas, M, Nonier, MF, Gaulejac, NV, Absalon, C, Bertrand, A and Mirabel, M. Differentiation of proanthocyanidin tannins from seeds, skins and sterns of grapes (Vitis vinifera) and heartwood of Quebracho (Schinopsis balansae) by matrix-assisted laser desorption/ionization time-of- flight mass spectrometry and thioacidolysis/liquid chromatography/electrospray ionization mass spectrometry. Analytica Chimica Acta 513: 247-256. 2004 https://doi.org/10.1016/j.aca.2003.11.085
  10. Hwang, SY, Kim SI, Kim, SH, Kwak, YS and Jeong YJ. Effect of Korean red ginseng on clinical chemical parameters in male guinea pigs exposed acutely to 2,3,7,8-tetrachlorobenzo-${\rho}$-dioxin. J. Korean Soc. Food Sci. Nutr. 28:1349-1354. 1999
  11. Ha, BJ. Effects of Houttuynia Cordata thumb on antioxidative activity against TCDD damage. J. Environ. Sci. 12:599-603. 2003 https://doi.org/10.5322/JES.2003.12.6.599
  12. Lind, PM, Larsson, S, Johansson, MH, Wikstrom, M, Lindhe, O and Orberg. Bone tissue composition, dimension and strength in female rat given an increased dietary level of vitamin A or exposed to 3,3',4,4', 5-pentcWorobiphenyl(PCB126) alone or incombination with vitamin C. Toxicol. 151:11-23. 2000 https://doi.org/10.1016/S0300-483X(00)00262-6
  13. Hwang, SY, Yang, JB, Chang, CS, Lee, YC and Lee, HC. Protective effect of Cornu Cervi Parvum extract on toxicity induced by 2,3,7 ,8-tetrachlorobenzo-${\rho}$-dioxin in rat, Kor. J. Ori. Physiol. Pethol. 16:674- 679. 2002
  14. Ha, BJ. Effects of Saururus chinensis Baill on lipid metabolism against TCDD damage. J. Food Hyg. Saf. 18:166-170. 2003
  15. Beuege, JA and Aust, SD. Microsoma11ipid peroxidation. Methods Enzymology 105: 302-310. 1978
  16. Masalkar, PD and Abhang, SA. Oxidative stress and antioxidant status in patients with alcoholic liver disease. Clinica Chimica Acta 355:61-65. 2005 https://doi.org/10.1016/j.cccn.2004.12.012
  17. Kollar, P, Kotolova, H, Necas, J, Karpisek, M, Bartosikova, L and Karesova, P. Experimental study of resveratrol and flaconoids in red wine with regard to their possible hypolipemic effects. Vnitr. Lek. 46:856-860. 2000
  18. Castelli, WP, Garrison, RJ, Wilson, PWF, Abbott, RD, Kalousdian, S and Kannel, WB. Incidence of coronary heart disease and lipoprotein cholesterol levels, the Framingham study. JAMA 256:2835-2838. 1986 https://doi.org/10.1001/jama.256.20.2835
  19. Gordon, T, Castelli, WP and Dawber, TR. Lipoprotein, cardiovascular disease and death, the Framingham study. Arch. Int. Med. 141:1128-1135. 1981 https://doi.org/10.1001/archinte.141.9.1128
  20. Shon, YH, Park, IK, Moon, IS, Chang, HW, Park, IK and Nam, KS. Effect of chitosan oligosaccharide on 2,3,7,8-tetracWorodibenzo-${\rho}$-dioxin-induced oxidative stress in mice. Biol. Pharm. Bull. 25:1161-1164. 2002 https://doi.org/10.1248/bpb.25.1161
  21. Bidlack, WR and Tappel, AL. Damage to microsomal membrane by lipid peroxidation. Lipids 8:177-178. 1973 https://doi.org/10.1007/BF02544631
  22. Saito, M. International between lipid peroxide formation and nutritional status. J. Jpn. Soc. Nutr. Food Sci. 41:343-349. 1988 https://doi.org/10.4327/jsnfs.41.343