Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Clinico-epidemiologic Study of Henoch-Schönlein Purpura in Children, 1987 through 2003

Henoch-Schönlein 자반증의 임상 역학적 연구(1987-2003년)

  • Choi, Sun-Mee (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
  • Lee, Kyung-Yil (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
  • 최선미 (가톨릭대학교 의과대학 소아과학교실) ;
  • 이경일 (가톨릭대학교 의과대학 소아과학교실)
  • Received : 2004.08.11
  • Accepted : 2004.10.04
  • Published : 2005.02.15
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Abstract

Purpose : We evaluated children with Henoch-$Sch{\ddot{o}}nlein$ purpura(HSP) in terms of epidemiology and clinical characteristics. Methods : A total of 424 medical records of children with HSP admitted to The Catholic University of Korea, Daejeon St. Mary's Hospital, from 1987 to 2003 were retrospectively analyzed. Results : The mean annual number of cases was $25.1{\pm}7.9$ and no one year showed an outbreak. There was a steady number of patients throughout the year with a decrease during the summer season. The male-to-female ratio was 1.3 : 1 with the median age of the patients being 6-years-old. The age distribution showed a peak at age 6 in a bell-shaped distribution curve. Purpura was noted in 100 percent of the patients, gastrointestinal involvement in 53.8 percent, joint involvement in 40.8 percent, and renal involvement in 18.9 percent. Nephrotic syndrome occurred in 1 percent of all patients. Conclusion : The epidemiologic and clinical features of HSP were similar to those of other regions in Korea and foreign nations, irrespective of time.

목 적 : HSP로 진단된 환아들에서 역학, 임상양상 및 경과를 알아보고자 하였다. 방 법 : 1987년 1월부터 2003년 12월까지 가톨릭대학교 대전 성모병원에 입원하여 HSP로 진단받은 424명의 환아를 대상으로 환아의 의무기록을 통해 임상 양상 및 역학적 지표들을 조사 분석하였다. 결 과 : 연간 평균 발생 수는 $25.1{\pm}7.9$명이었고, 연도별 발생은 일정한 주기를 보이지 않았다. 일년을 통해 지속적인 발생이 있었으나 하절기에 발생이 적었다. 남녀비는 1.3 : 1이었고, 평균 연령은 6.6세이었다. 연령분포는 4-6세를 정점으로 종형의 분포를 보였고 92.7%의 환아가 2-11세 사이에 발생하였다. 임상 증상으로 자반은 100%, 위장 증상이 53.8%, 관절 증상 40.8%, 신장 증상이 18.9%에서 나타났으며, 신증후군은 1%의 환아에서 관찰되었다. 결 론 : 이번 연구에서의 HSP의 임상 및 역학적 특성은 시대적인 변화 없이 미국을 비롯한 외국과 국내의 이전 보고들과 거의 유사하였다.

Keywords

References

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