Molecules and Cells

  • 제19권3호
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  • Pages.303-309
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  • 2005
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
권호 표지

The Pleiotropy of Telomerase against Cell Death

  • Sung, Young Hoon (Department of Molecular Cell Biology, Samsung Biomedical Research Institute, SungKyunkwan University School of Medicine) ;
  • Choi, Yoon Sik (Department of Molecular Cell Biology, Samsung Biomedical Research Institute, SungKyunkwan University School of Medicine) ;
  • Cheong, Cheolho (Department of Molecular Cell Biology, Samsung Biomedical Research Institute, SungKyunkwan University School of Medicine) ;
  • Lee, Han-Woong (Department of Molecular Cell Biology, Samsung Biomedical Research Institute, SungKyunkwan University School of Medicine)
  • 투고 : 2005.06.13
  • 심사 : 2005.06.15
  • 발행 : 2005.06.30
⟨ 이전 논문 다음 논문 ⟩

초록

The end of eukaryotic genomic DNA is capped by a specialized structure called as "telomere" which consists of the repetitive array of nucleotide sequence, TTAGGG, in humans and mice, and a variety of binding proteins. Telomerase is a ribonucleoprotein (RNP) complex responsible for the elongation of telomeres to maintain the genomic integrity, and is composed of telomerase reverse transcriptase (TERT), telomerase RNA component (TERC), and their associated factors regulating the catalytic activity of telomerase. Although it is now apparent that telomerase protects cells from apoptosis via the maintenance of genomic integrity by stabilizing telomeres, our understanding for the physiological role of telomerase is yet far from completion, and emerging evidence suggests that telomerase has additional extratelomeric roles in mediating cell survival and anti-apoptotic functions against various cytotoxic stresses. Here we summarize and discuss how telomerase and telomeres are involved in mediating cellular protection against apoptosis.

키워드

과제정보

연구 과제 주관 기관 : MOST, KOSEF

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