Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
권호 표지

A Combined Approach for Locating Box H/ACA snoRNAs in the Human Genome

  • Eo, Hae Seok (Program in Bioinformatics, Seoul National University) ;
  • Jo, Kwang Sun (JLLAB, Inc.) ;
  • Lee, Seung Won (JLLAB, Inc.) ;
  • Kim, Chang-Bae (National Genome Information Center, Korea Research Institute of Bioscinece and Biotechnology) ;
  • Kim, Won (School of Biological Sciences, Seoul National University)
  • Received : 2004.10.10
  • Accepted : 2005.04.06
  • Published : 2005.08.31
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Abstract

A novel combined method for locating box H/ACA small nucleolar RNAs (snoRNAs) is described, together with a software tool. The method adopts both a probabilistic hidden Markov model (HMM) and a minimum free energy (MFE) rule, and filters possible candidate box H/ACA snoRNAs obtained from genomic DNA sequences. With our novel method 12 known box H/ACA snoRNAs, and one strong candidate were identified in 30 nucleolar protein genomic sequences.

Keywords

Acknowledgement

Supported by : Korea Research Foundation

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