Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
권호 표지

Principle and Application of Immunotherapy in Women with Recurrent Pregnancy Losses and Infertility of Implantation Failures: Intravenous Immunoglobulin G Infusion Treatment

  • Kwak, Joanne Young Hee (Department of Obstetrics and Gynecology, Department of Microbiology and Immunology,Rosalind Franklin University of Medicine and Science,The Chicago Medical School)
  • Published : 2005.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Keywords

References

  1. Coulam CB. Epidemiology of recurrent spontaneous abortion. Am J Reprod Immunol 1991; 26: 23-7. https://doi.org/10.1111/j.1600-0897.1991.tb00692.x
  2. Mueller-Eckhardt G, Heine O, Neppert J, Kunzel W, Mueller-Eckhardt C. Prevention of recurrent spontaneous abortion by intravenous immunoglobulin. Vox Sang 1989; 56: 151-4 https://doi.org/10.1111/j.1423-0410.1989.tb03040.x
  3. Dietrich G, Kaveri S, Kazatchkine MD. Modulation of autoimmunity by intravenous immune globulin through interaction with the function of the immune/ 1diotypic network. Clin Immuno Immunopathol 1992; 62: 73-81 https://doi.org/10.1016/0090-1229(92)90016-H
  4. Scott JR, Branch W, Kochenour NK, Ward K. Intravenous immunoglobulin treatment of pregnant patients with recurrent pregnancy loss caused by antiphospholipid antibodies and Rh immunization. Am J Obstet Gynecol 1988; 159: 1055-6 https://doi.org/10.1016/0002-9378(88)90411-5
  5. Kwak JY, Beaman KD, Gilman-Sachs A, Ruiz JE, Schewitz D, Beer AE. Up-regulated expression of CD56+, CD56+/CD16+, and CD19+ cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses. Am J Reprod Immunol 1995; 34: 93-9 https://doi.org/10.1111/j.1600-0897.1995.tb00924.x
  6. Rigal D, Vermot-Desroches C, Heitz S, Bemaud J, Alfonsi F, Monier Jc. Effects of intravenous immunoglobulins (lVIG) on peripheral blood B, NK, and T cell subpopulations in women with recurrent spontaneous abortions: specific effects on LFA-l and CD56 molecules. Clin Immunol Immunopathol 1994; 71: 309-14 https://doi.org/10.1006/clin.1994.1091
  7. Piccinni MP, Scaletti C, Maggi E, Romagnani S. Role of hormone-controlled Thl- and Th2-type cytokines in successful pregnancy. J Neuroimmunol 2000; 109: 30-3 https://doi.org/10.1016/S0165-5728(00)00299-X
  8. Raghupathy R, Makhseed M, Azizieh F, Omu A, Gupta M, Farhat R. Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum Reprod 2000; 15: 713-8 https://doi.org/10.1093/humrep/15.3.713
  9. Vives A, Balasch J, Yague J, Quinto L, Ordi J, Vanrell JA. Type-l and type-2 cytokines in human decidual tissue and trophoblasts from normal and abnormal pregnancies detected by reverse transcriptase polymerase chain reaction (RT-PCR). Am J Reprod Immunol 1999; 42: 361-8 https://doi.org/10.1016/S0165-0378(98)00077-1
  10. Coulam CB, Clark DA. Controversies in diagnosis and management of recurrent spontaneous abortion. Am J Repro Immunol 1997; 37: 279-82 https://doi.org/10.1111/j.1600-0897.1997.tb00230.x
  11. Gleicher N, Pratt D, Dudkiewicz A. What do we really know about autoantibody abnormalities and reproductive failure: a critical review. Autoimmunity 1993; 16: 115-40 https://doi.org/10.3109/08916939308993318
  12. Drake BL, Head JR. Murine trophoblast can be killed by allospecific cytotoxic T lymphocytes generated in GIBCO Opti-MEM medium. J Reprod Immunol 1989; 15: 71-7 https://doi.org/10.1016/0165-0378(89)90040-5
  13. King A, Loke YW. Human trophoblast and JEG choriocarcinoma cells are sensitive to lysis by IL-2stimulated decidual NK cells. Cell Immunol 1990; 129: 435-48 https://doi.org/10.1016/0008-8749(90)90219-H
  14. Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A, et al. Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod 2001;16: 855-61 https://doi.org/10.1093/humrep/16.1.1
  15. Lachapelle MH, Miron P, Hemmings R, Roy DC. Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome. J Immunol 1996; 156: 4027-34
  16. Roussev RG, Higgins NG, McIntyre JA. Phenotypic characterization of normal human placental mononuclear cells. J Reprod Immunol 1993; 25: 15-29 https://doi.org/10.1016/0165-0378(93)90039-K
  17. Kwak JYH, Beer AE, Kim SH, Mantouvalos HP. Immunopathology of the implantation site utilizing monoclonal antibodies to natural killer cells in women with recurrent pregnancy losses. AJRI 1999; 41:91-8 https://doi.org/10.1111/j.1600-0897.1999.tb00070.x
  18. Beer AE, Kwak JY, Ruiz IE. Immunophenotypic profiles of peripheral blood lymphocytes in women with recurrent pregnancy losses and in infertile women with multiple failed in vitro fertilization cycles. Am J Reprod Immunol 1996; 35: 376-82 https://doi.org/10.1111/j.1600-0897.1996.tb00497.x
  19. Aoki K, Kajiura S, Matsumoto Y, et al. Preconceptional natural-killer-cell activity as a predictor of miscarriage. Lancet 1995; 345: 1340-2 https://doi.org/10.1016/S0140-6736(95)92539-2
  20. Coulam CB. Immunotherapy for recurrent spontaneous abortion. Early Pregnancy 1995; 1: 13-26
  21. Higuchi K, Aoki K, Kimbara T, Hosoi N, Yamamoto T, Okada H. Suppression of natural killer cell activity by monocytes following immunotherapy for recurrent spontaneous aborters. Am J Reprod Immunol 1995; 33: 221-7 https://doi.org/10.1111/j.1600-0897.1995.tb00888.x
  22. Abadia-Molina AC, Ruiz C, Montes MI, King A, Loke YW, Olivares EG. Immune phenotype and cytotoxic activity of lymphocytes from human term decidua against trophoblast. J Reprod Immunol 1996; 31: 109-23 https://doi.org/10.1016/0165-0378(96)00965-5
  23. Worldwide collaborative observational study and meta-analysis on allogenic leukocyte immunotherapy for recurrent spontaneous abortion. Recurrent Miscarriage Immunotherapy Trialists Group. Am J Reprod Immunol 1994; 32: 55-72 https://doi.org/10.1111/j.1600-0897.1994.tb01095.x
  24. Beer AE, Kwak JYH, Beaman KD, Gilman-Sachs A. Antiphospholipid antibodies in women with recurrent pregnancy losses: Elicitation, expression and therapy. In: Dondero P, Johnson PM, eds. Reproductive immunology. New York: Raven Press, 1992 (vol 97)
  25. Christiansen OB, Pedersen B, Rosgaard A, Husth M. A randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin in the prevention of recurrent miscarriage: evidence for a therapeutic effect in women with secondary recurrent miscarriage. Hum Reprod 2002; 17: 809-16 https://doi.org/10.1093/humrep/17.3.809
  26. Christiansen OB, Mathiesen O, Husth M, et al. Placebo-controlled trial of treatment of unexplained secondary recurrent spontaneous abortions and recurrent late spontaneous abortions with i.v, immunoglobulin. Hum Reprod 1995; 10: 2690-5 https://doi.org/10.1093/oxfordjournals.humrep.a135769
  27. Clark DA, Gunby J, Daya S. The use of allogeneic leukocytes or IV IgG for the treatment of patients with recurrent spontaneous abortions. Transfusion Med. Rev. 1997; 11: 85-94 https://doi.org/10.1053/tm.1997.0110085
  28. Pierangeli SS, Espinola RG, Uu X, Harris EN. Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-I, vascular cell adhesion molecule-I, and P-selectin. Circ Res 2001; 88: 245-50 https://doi.org/10.1161/01.RES.88.2.245
  29. Heilmann L, Berg C, von Tempelhoff GP, Gehler J, Zimmer B, Wolf H. [Intravenous immunoglobulins (IVIG) in treatment of an antiphospholipid syndrome in pregnancy]. Z Geburtshilfe Neonatol 1998; 202: 164-7.
  30. Vaquero E, Lazzarin N, Valensise H, et al. Pregnancy outcome in recurrent spontaneous abortion associated with antiphospholipid antibodies: a comparative study of intravenous intmunoglobulin versus prednisone plus low-dose aspirin. Am J Reprod ImmunoI 2001;45: 174-9 https://doi.org/10.1111/j.8755-8920.2001.450101.x
  31. Sherer Y, Shoenfeld Y. Antiphospholipid syndrome: insights from animal models. Curr Opin Hematol 2000; 7: 321-324 https://doi.org/10.1097/00062752-200009000-00011
  32. Gordon C, Kilby MD. Use of intravenous immunoglobulin therapy in pregnancy in systemic lupus erythematosus and antiphospholipid antibody syndrome. Lupus 1998; 7: 429-33 https://doi.org/10.1191/096120398678920451
  33. Stricker RB, Steinleitner A, Bookoff CN, Weckstein LN, Winger EE. Successful treatment of immunologic abortion with low-dose intravenous immunoglobulin. Fertil Steril 2000; 73: 536-40. https://doi.org/10.1016/S0015-0282(99)00572-5
  34. Branch DW, Porter TF, Paidas MJ, Belfort MA, Gonik B. Obstetric uses of intravenous immunoglobulin: successes, failures, and promises. J Allergy Clin Immunol 2001; 108: S 133-8 https://doi.org/10.1067/mai.2001.117052
  35. Hachulla E, Piette AM, Hatron PY, Bletry O. [Aspirin and antiphospholipid syndrome]. Rev Med Interne 2000; 21: 83s-8s. https://doi.org/10.1016/S0248-8663(00)87232-X
  36. Harris EN, Pierangeli SS. Utilization of intravenous immunoglobulin therapy to treat recurrent pregnancy loss in the antiphospholipid syndrome: a review. Scand J Rheumatol Suppl 1998; 107: 97-102
  37. Sher G, Matzner W, Feinman M, et al. The selective use of heparin/aspirin therapy, alone or in combination with intravenous immunoglobulin G, in the management of antiphospholipid antibody-positive women undergoing in vitro fertilization. Am J Reprod Immunol 1998; 40: 74-82 https://doi.org/10.1111/j.1600-0897.1998.tb00394.x
  38. Coulam CB, Clark DA, Collins JA. Worldwide prospective collaborative observational study and metaanalysis on immunotherapy for recurrent spontaneous abortion. N Eng J Med 1994: In Press