The Effect of Transforaminal Epidural Block with Hyaluronidase and Triamcinolone

Hyaluronidase를 사용한 경추간공 경막외 차단의 효과

  • 조대현 (포천중문의과대학교 분당차병원 통증클리닉) ;
  • 홍지희 (포천중문의과대학교 분당차병원 통증클리닉) ;
  • 김명희 (포천중문의과대학교 분당차병원 마취통증의학교실)
  • Received : 2005.09.20
  • Accepted : 2005.12.09
  • Published : 2005.12.10

Abstract

Background: Epidural steroid injections benefit certain patients with radicular pain, and often have only a limited duration. We compared the efficacy of hyaluronidase and triamcinolone and triamcinolone alone in patients with lumbar herniated disc disease treated with transforaminal epidural block. Methods: Forty patients who had undergone a transforaminal epidural injection were retrospectively reviewed. The T group received triamcinolone and local anesthetics; whereas, the HT group received hyaluronidase, triamcinolone and local anesthetics. We evaluated the improvement as being good, moderate, mild or no improvement, and in those where the improvement was good or moderate, also evaluated the duration of pain relief. Data were collected from the medical records of patients or via phone calls, which were analyzed using Student t- and chi-squared tests. A value of P < 0.05 was considered significant. Results: There were no significant differences in the degree of pain improvement or duration of pain relief between the two groups. Conclusions: A hyaluronidase and triamcinolone injection during transforaminal epidural block has on benefit with respect to the degree of pain improvement or its duration compared to a triamcinolone only injection.

Keywords

References

  1. McLain RF, Kapural L, Mekhail NA: Epidural steroid therapy for back and leg pain: mechanisms of action and efficacy. Spine] 2005; 5: 191-201.
  2. White AH, Derby R, Wynne G: Epidural injections for the diagnosis and treatment of low-back pain. Spine 1980; 5: 78-86.
  3. Lee K], Han SG, Yoon SH, Kim JS, Lee YS: Nerve root block with corticosteroids, hyaluronidase, and local anesthetic in the failed back surgery syndrome. Korean J Pain 1999; 12: 191-4.
  4. Hayashi N, Weinstein ]N, Meller ST, Lee HM, Spratt KF, Gebhart GF: The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy. Spine 1998; 23: 877-85.
  5. Olmarker K: Spinal nerve root compression: nutrition and function of the porcine cauda equina compressed in vivo. Acta Orrhop Scand 1991; 242(supp!): 1-27.
  6. Rydevik B, Brown MD, Lundborg G: Parhoanarorny and pathophysiology of nerve root compression. Spine 1984; 9: 7-15.
  7. Boden SD, Davis DO, Dina TS, Patronas NJ, Wiesel SW: Abnormal magnetic resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am 1990; 72: 403-8.
  8. Takebayashi T, Cavanaugh JM, Cuneyt OA, Kalliguri S, Chen C: Effect of nucleus pulposus on the activity of dorsal root ganglion. Spine 2001; 26: 940-5.
  9. Howe JF, Loeser JD, Calvin WH: Mechanosensitivity of dorsal root ganglia and chronically injured axons: a physiological basis for the radicular pain of nerve root compression. Pain 1977; 3: 25-41.
  10. Devor M, Obermayer M: Membrane differentiation in rat dorsal root ganglia and possible consequences for back pain. Neurosci Lett 1984; 51: 341-6.
  11. Jo DH: Transforaminal epidural steroid injection used in the journal of the Korean pain society. The Korean Pain Society The Fourty Scientific Meeting: 2005. 5: Daegu.
  12. Saal JS, Franson RC, Dobrow R, Saal JA, White AH, Goldthwaite N: High levels of inflammatory phospholipase A2 activity in lumbar disc herniatioins, Spine 1990; 15: 674-8.
  13. Berman AT, Garbarino JL, Fischer SM, Bosacco SJ: The effects of epidural injection of local anesthetics and corticosteroids on patients with lumbosciatic pain. Clin Orthop Relat Res 1984; 188: 144-51.
  14. Ridley MG, Kingsley GH, Gibson T, Grahame R: Outpatient lumbar epidural corticosteroid injection in the mamagement of sciatica. Br J Rheumarol 1988; 27: 295-9.
  15. Bush K, Hiller S: A controlled study of caudal epidural injections of triamcinolone plus procaine for the management of intractable sciatica. Spine 1991; 16: 572-5.
  16. Karppinen J, Malmivaara A, Kurunlahti M, Kyllonen E, Pienimaki T, Nierninen P, et al: Periradicular infiltration for sciatica: a randomized controlled trial. Spine 2001; 26: 1059-67.
  17. Devulder J: Transforaminal nerve root sleeve injection with corticosteroids, hyaluronidase, and local anesthetic in the failed back surgery syndrome. J Spinal Disord 1998; 11: 151-4.
  18. Borg PA, Krijnen HJ: Hyaluronidase in the management of pain due to post-lamicectomy scar tissue. Pain 1994; 58: 273-6.
  19. Heavner JE, Racz GB, Raj P: Percutaneous epidural neuroplasty: Prospective evaluation of 0.9% NaCl versus 10% NaCl with or without hyaluronidase. Reg Anesth Pain Med 1999; 24: 202-7.
  20. Jung SS, Lee WH: Comparison of transforaminal epidural steroid injection and lumbar/caudal epidural steroid injection for the treatment of lumbosacral radiculopathy. Korean J Pain 2005; 18: 23-8.