The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Study for the Antinociceptive Effect and Toxicity of Chronic Intrathecal Infusion of Cannabinoids in Rats

백서의 척수강 내로 장기간 투여한 Cannabinoids의 진통 효과 및 독성에 관한 연구

  • Yoon, Myung Ha (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Bae, Hong Buem (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Choi, Jeong II (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Bae, Chun Sang (Departments of Anatomy, Medical School, Chonnam National University) ;
  • Kim, Seok Jae (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Chang Mo (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Jeong, Sung Tae (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Kwang Su (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Jin, Won Jong (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Jong Pil (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University) ;
  • Kim, Jong Sik (Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University)
  • 윤명하 (전남대학교 의과대학 마취통증의학교실) ;
  • 배홍범 (전남대학교 의과대학 마취통증의학교실) ;
  • 최정일 (전남대학교 의과대학 마취통증의학교실) ;
  • 배춘상 (전남대학교 의과대학 해부학교실) ;
  • 김석재 (전남대학교 의과대학 마취통증의학교실) ;
  • 김창모 (전남대학교 의과대학 마취통증의학교실) ;
  • 정성태 (전남대학교 의과대학 마취통증의학교실) ;
  • 김광수 (전남대학교 의과대학 마취통증의학교실) ;
  • 진원종 (전남대학교 의과대학 마취통증의학교실) ;
  • 김종필 (전남대학교 의과대학 마취통증의학교실) ;
  • 김종식 (전남대학교 의과대학 마취통증의학교실)
  • Received : 2005.09.23
  • Accepted : 2005.12.13
  • Published : 2005.12.10
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Abstract

Background: Cannabinoids have shown antinociceptive action. The aims of this study were to examine the effect of chronic infusion of a cannabinoids receptors agonist (WIN 55,212-2) for thermal nociception at the spinal level, and to also observe the development of toxicity. Methods: Male Sprague-Dawley rats were implanted with lumbar intrathecal catheters with the nociceptive response (withdrawal response latency) determined by exposing the plantar surface of the hindpaw to radiant heat. Initially, the effect of intrathecal WIN 55,212-2 was evaluated followed by the change in the effect at 1, 2, 3 and 4 weeks after repeated infusion. Finally, the histopathological findings were assessed 1 and 4 weeks following the infusion of WIN 55,212-2. Results: Intrathecal WIN 55,212-2 was found to produce a limited antinociception during the thermal test. %MPE of WIN 55,212-2 at 1, 2, 3, and 4 weeks after infusion was not different from each other. No abnormal pathological findings were observed following a chronic intrathecal infusion of WIN 55,212-2. Conclusions: WIN 55,212-2, a cannabinoids receptors agonist, may be useful in the management of thermal nociception, without changing the effectiveness or causing the toxicity following a chronic infusion at the spinal level.

Keywords

Acknowledgement

Supported by : 전남대학교

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