Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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The Injectable Fibroblast-Hyaluronic Acid Complex for Augmentation Rhinoplasty

Hyaluronic Acid와 배양된 섬유모세포의 혼합주입을 이용한 융비술

  • Shin, Seung-Han (Department of Plastic and Reconstructive Surgery, Korea University College of Medicine) ;
  • Han, Seung-Kyu (Department of Plastic and Reconstructive Surgery, Korea University College of Medicine) ;
  • Lee, Byung-Il (Department of Plastic and Reconstructive Surgery, Korea University College of Medicine) ;
  • Kim, Woo-Kyung (Department of Plastic and Reconstructive Surgery, Korea University College of Medicine)
  • 신승한 (고려대학교 의과대학 성형외과학교실) ;
  • 한승규 (고려대학교 의과대학 성형외과학교실) ;
  • 이병일 (고려대학교 의과대학 성형외과학교실) ;
  • 김우경 (고려대학교 의과대학 성형외과학교실)
  • Received : 2005.04.09
  • Published : 2005.09.10
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Abstract

Although several suspension biomaterials have been considered to be relatively safe and convenient, varying degrees of resorption have required repeated percutaneous injection. In the previous animal study the authors have reported that cultured human fibroblasts suspended in $Restylane^{(R)}$, which is modified hyaluronic acid, could produce human dermal matrices and prolong the effect of this gel. This study was undertaken to evaluate the clinical efficacy of this method. A total of 11 patients ranging from 25 to 57 years of age were included in this study between January of 2002 and December of 2003. All the patients were treated for the purpose of augmentation rhinoplasty. $1{\times}10^7/ml$ or $1.5{\times}10^7/ml$ cultured fibroblasts were suspended in 0.7 to 1.4 ml of $Restylane^{(R)}$. The implants were transferred to a 1-ml syringe and injected subcutaneously to the nose of the patients. Among 11 patients, long term follow-up for more than 1 year was possible in 6 patients. The injected implants remained in site without evidence of resorption or loss of correction. All the patients were satisfied with long term results of this method. There was no complication during the follow-up period.

Keywords

References

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